{"id":175659,"date":"2026-10-26T11:00:44","date_gmt":"2026-10-26T11:00:44","guid":{"rendered":"https:\/\/blog.m3globalresearch.com\/blog\/?p=175659"},"modified":"2026-10-26T15:28:01","modified_gmt":"2026-10-26T15:28:01","slug":"inflammaging-how-chronic-low-grade-inflammation-drives-age-related-disease","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/inflammaging-how-chronic-low-grade-inflammation-drives-age-related-disease\/","title":{"rendered":"Inflammaging: How Chronic Low-Grade Inflammation Drives Age-Related Disease"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"175659\" class=\"elementor elementor-175659\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2c08d e-con e-atomic-element e-flexbox-base e-d693f31 \" data-id=\"7b2c08d\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"7b2c08d\" data-e-type=\"e-flexbox\" data-id=\"7b2c08d\">\n    \t\t<div class=\"elementor-element elementor-element-b12c334 elementor-widget elementor-widget-text-editor\" data-id=\"b12c334\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>As the body ages, subtle changes in immune function can fuel persistent, low-grade inflammation, a phenomenon scientists call \u201cinflammaging.\u201d This process is increasingly recognised as a contributor to cardiovascular disease, neurodegeneration, metabolic disorders and physical frailty in older adults.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f241f77 elementor-widget elementor-widget-text-editor\" data-id=\"f241f77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Inflammaging develops through several interconnected mechanisms. Immunosenescence, the age-related decline in immune function, impairs the body\u2019s ability to clear damaged or senescent cells. Meanwhile, telomere shortening, mitochondrial dysfunction and oxidative stress promote cellular damage. These damaged cells release molecules that activate inflammatory pathways, creating a self-reinforcing cycle.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bcdb794 elementor-widget elementor-widget-text-editor\" data-id=\"bcdb794\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>At the molecular level, inflammaging involves dysregulated signalling of inflammatory markers including interleukin-6, IL-1\u03b2 and tumour necrosis factor-alpha. Senescent cells that resist normal programmed cell death produce what scientists term the senescence-associated secretory phenotype (SASP), which includes inflammatory cytokines that can damage surrounding healthy tissues.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c1081fb elementor-widget elementor-widget-text-editor\" data-id=\"c1081fb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The gut microbiome also plays a role. Ageing can alter microbial composition and diversity, potentially impairing intestinal barrier function. When microbial products cross this barrier, they can stimulate immune receptors and sustain systemic inflammation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05d7226 elementor-widget elementor-widget-text-editor\" data-id=\"05d7226\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Lifestyle factors offer non-pharmacological approaches to reducing chronic inflammation. Regular physical activity can lower resting C-reactive protein and TNF-\u03b1 levels, whilst diets rich in fibre and plant-based foods support gut microbial health and immune regulation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0b60924 elementor-widget elementor-widget-text-editor\" data-id=\"0b60924\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Emerging research is investigating pharmacological interventions, including senolytics that selectively clear senescent cells. However, evidence for their benefits in preventing age-related disease in humans remains limited. Any intervention must balance reducing persistent inflammation with preserving immune responses needed for pathogen clearance and tissue repair.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb5aaf1 elementor-widget elementor-widget-text-editor\" data-id=\"bb5aaf1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Source: News Medical overview article drawing on multiple peer-reviewed sources including Teissier T et al. Cells (2022); Furman D et al. Nature Medicine (2019); Ferrucci L &amp; Fabbri E. Nature Reviews Cardiology (2018).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Inflammaging involves age-related changes in immune function and chronic inflammation, raising risks of heart disease, frailty and metabolic disorders.<\/p>\n","protected":false},"author":11,"featured_media":175707,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"categories":[3200],"tags":[],"class_list":["post-175659","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v28.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Inflammaging: How Chronic Low-Grade Inflammation Drives Age-Related Disease<\/title>\n<meta name=\"description\" content=\"Artificial 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