{"id":174816,"date":"2026-09-28T09:18:06","date_gmt":"2026-09-28T09:18:06","guid":{"rendered":"https:\/\/www.m3globalresearch.com\/blog\/?p=174816"},"modified":"2026-09-28T09:18:11","modified_gmt":"2026-09-28T09:18:11","slug":"menopause-temporarily-slows-brain-grey-matter-loss-brain-scan-study-finds","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/menopause-temporarily-slows-brain-grey-matter-loss-brain-scan-study-finds\/","title":{"rendered":"Menopause Temporarily Slows Brain Grey Matter Loss, Brain Scan Study Finds"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"174816\" class=\"elementor elementor-174816\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2c08d e-con e-atomic-element e-flexbox-base e-d693f31 \" data-id=\"7b2c08d\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"7b2c08d\" data-e-type=\"e-flexbox\" data-id=\"7b2c08d\">\n    \t\t<div class=\"elementor-element elementor-element-b12c334 elementor-widget elementor-widget-text-editor\" data-id=\"b12c334\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A longitudinal brain scan study published in Nature Communications found that the transition to menopause is associated with a temporary slowing of cortical grey matter loss, a pattern that contrasts with the accelerated grey matter reduction seen during puberty and pregnancy. The research, led by cognitive neuroscientist Sophie van &#8216;t Hof at Amsterdam University Medical Center, is the first to examine whole-brain grey matter change across the menopause transition.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f241f77 elementor-widget elementor-widget-text-editor\" data-id=\"f241f77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The study repeatedly scanned the brains of more than 1,000 participants at various life stages, including puberty, pregnancy, and the pre- and post-menopausal periods, over several years. During puberty and pregnancy, cortical grey matter loss accelerated, a pattern consistent with the brain reorganising its tissue in response to significant hormonal changes, including steep rises in oestrogen and progesterone.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bcdb794 elementor-widget elementor-widget-text-editor\" data-id=\"bcdb794\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The menopause transition showed the opposite pattern. Rather than accelerating, the gradual age-related decline in total cortical volume and grey matter appeared to slow or pause during the transition period. Participants who moved from a pre-menopausal to a menopausal state during the study did not show the same grey matter declines as those who remained consistently pre- or post-menopausal throughout. These findings were consistent regardless of age, hormone replacement therapy use, or number of pregnancies.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-05d7226 elementor-widget elementor-widget-text-editor\" data-id=\"05d7226\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The brain changes during the menopause transition tended to occur in regions known to be influenced by oestrogen, suggesting a possible hormonal connection, though the study cannot establish causation. Hormone levels were not directly measured, and participants self-reported their menopausal stage. The authors describe the findings as preliminary and call for further research, noting that fewer than 6% of neuroscience studies are conducted exclusively in female participants.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb5aaf1 elementor-widget elementor-widget-text-editor\" data-id=\"bb5aaf1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Source: Cassella C. Menopause May Temporarily Alter Your Brain&#8217;s Normal Aging, Scans Reveal. ScienceAlert, 20 September 2026. Primary study: Van &#8216;t Hof S et al. Nature Communications (2026).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>The menopause transition may temporarily slow cortical grey matter loss, revealing distinct brain changes during menopause, a study finds.<\/p>\n","protected":false},"author":11,"featured_media":174876,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[3200],"tags":[],"class_list":["post-174816","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v28.2) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Menopause Temporarily Slows Brain Grey Matter Loss, Brain Scan Study Finds<\/title>\n<meta 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