{"id":173589,"date":"2026-08-17T10:10:37","date_gmt":"2026-08-17T10:10:37","guid":{"rendered":"https:\/\/www.m3globalresearch.com\/blog\/?p=173589"},"modified":"2026-08-17T10:10:42","modified_gmt":"2026-08-17T10:10:42","slug":"psa-level-below-0-2-ng-ml-linked-to-improved-survival-in-metastatic-prostate-cancer","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/psa-level-below-0-2-ng-ml-linked-to-improved-survival-in-metastatic-prostate-cancer\/","title":{"rendered":"PSA Level Below 0.2 ng\/mL Linked to Improved Survival in Metastatic Prostate Cancer"},"content":{"rendered":"\t\t
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Patients with metastatic prostate cancer whose prostate-specific antigen (PSA) levels drop below 0.2 ng\/mL after treatment have significantly better survival outcomes, according to a real-world study published in Cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Researchers analysed Veterans Health Administration data on 4,890 patients who received testosterone deprivation therapy with or without additional treatments between 2018 and 2023 for metastatic hormone-sensitive prostate cancer. Over a median follow-up of approximately two years, 896 patients died.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Patients whose PSA levels dropped below 0.2 ng\/mL within nine months of starting treatment were 54% less likely to die than those whose levels did not reach this threshold. This survival benefit was observed regardless of whether patients also achieved a 90% or greater PSA decline. Notably, patients who had at least a 90% PSA reduction but did not reach the 0.2 ng\/mL threshold showed no improvement in survival.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Whilst multiple phase 3 clinical trials have identified PSA below 0.2 ng\/mL as the optimal cutoff for determining prognosis, real-world data have been lacking. Physicians often use other metrics, such as percentage of PSA decline, to assess treatment response.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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The findings suggest that patients who do not achieve a PSA drop below 0.2 ng\/mL could be candidates for more aggressive treatments. Additionally, patients receiving testosterone deprivation therapy combined with another testosterone-blocking drug were more likely to reach the target threshold.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Corresponding author Dr Stephen Freedland, professor of urology at Cedars-Sinai and staff physician at the Durham VA Medical Center, stated that clinicians should target PSA below 0.2 ng\/mL as the metric of success to optimise outcomes for patients with metastatic prostate cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Source: News Medical \/ Wiley (Cancer, 2026)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

Patients with Metastatic Prostate Cancer whose Prostate-Specific Antigen (PSA) falls below 0.2 ng\/mL may have better Survival Outcomes.<\/p>\n","protected":false},"author":11,"featured_media":173639,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","_monsterinsights_skip_tracking":false,"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[3200],"tags":[],"class_list":["post-173589","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news"],"acf":[],"yoast_head":"\nPSA Level Below 0.2 ng\/mL Linked to Improved Survival in Metastatic Prostate Cancer<\/title>\n<meta name=\"description\" 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