{"id":173230,"date":"2026-08-03T10:01:33","date_gmt":"2026-08-03T10:01:33","guid":{"rendered":"https:\/\/www.m3globalresearch.com\/blog\/?p=173230"},"modified":"2026-08-03T10:02:28","modified_gmt":"2026-08-03T10:02:28","slug":"licensed-ebola-vaccines-trigger-cross-reactive-antibodies-against-bundibugyo-virus","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/licensed-ebola-vaccines-trigger-cross-reactive-antibodies-against-bundibugyo-virus\/","title":{"rendered":"Licensed Ebola Vaccines Trigger Cross-Reactive Antibodies Against Bundibugyo Virus"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"173230\" class=\"elementor elementor-173230\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2c08d e-con e-atomic-element e-flexbox-base e-d693f31 \" data-id=\"7b2c08d\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"7b2c08d\" data-e-type=\"e-flexbox\" data-id=\"7b2c08d\">\n    \t\t<div class=\"elementor-element elementor-element-b12c334 elementor-widget elementor-widget-text-editor\" data-id=\"b12c334\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Vaccines designed for Zaire ebolavirus activated immune responses that also recognised the related Bundibugyo virus, according to research published in the <em>New England Journal of Medicine<\/em>. The findings suggest existing vaccine stockpiles could potentially offer some protection during current outbreaks where no specific vaccine exists.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f241f77 elementor-widget elementor-widget-text-editor\" data-id=\"f241f77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Uganda and the Democratic Republic of Congo are currently facing Bundibugyo virus outbreaks, which cause severe haemorrhagic fever with high fatality rates. No licensed vaccine or treatment exists specifically for this strain, and developing new vaccines takes years.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bcdb794 elementor-widget elementor-widget-text-editor\" data-id=\"bcdb794\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Researchers analysed 179 blood samples from adults and children in West Africa who had participated in the earlier PREVAC clinical trial. Participants had received one of two licensed Ebola vaccine regimens: a single-dose or booster version of the rVSV vaccine, or the two-dose Ad26.MVA vaccine. Samples were examined at 28 days and three months after vaccination.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65630bd elementor-widget elementor-widget-text-editor\" data-id=\"65630bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Using a multiplex Luminex assay, researchers tested whether antibodies generated against Zaire ebolavirus could recognise and bind to the glycoprotein of Bundibugyo virus. Both vaccine regimens generated cross-reactive antibodies detectable in blood samples. Although antibody responses were lower than those against the Zaire strain the vaccines were designed to target, Bundibugyo-recognising antibodies were clearly present.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9f354e elementor-widget elementor-widget-text-editor\" data-id=\"d9f354e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\">With the rVSV vaccine, these antibodies were detectable at 28 days and remained present at three months. For the Ad26.MVA vaccine, the antibody response strengthened at the three-month mark compared with one month.<\/p>\n<p class=\"font-claude-response-body break-words whitespace-normal\" dir=\"ltr\">The researchers clarified that whilst they demonstrated antibodies can bind to Bundibugyo virus, it remains unknown whether this is sufficient to prevent illness. Previous studies suggest glycoprotein-binding antibody levels are associated with protection after vaccination. Further clinical trials are needed to establish whether stockpiled vaccines can offer protection against Bundibugyo virus infection.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb5aaf1 elementor-widget elementor-widget-text-editor\" data-id=\"bb5aaf1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Source: Medical Xpress \/ New England Journal of Medicine (2026)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Vaccines for Zaire ebolavirus may also protect against Bundibugyo Virus, suggesting existing Ebola Vaccine stockpiles could aid outbreak response.<\/p>\n","protected":false},"author":11,"featured_media":173283,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[3200],"tags":[],"class_list":["post-173230","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Licensed Ebola Vaccines Trigger Cross-Reactive Antibodies Against Bundibugyo Virus<\/title>\n<meta name=\"description\" content=\"Vaccines for Zaire ebolavirus may 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