{"id":172982,"date":"2026-07-21T11:43:04","date_gmt":"2026-07-21T11:43:04","guid":{"rendered":"https:\/\/www.m3globalresearch.com\/blog\/?p=172982"},"modified":"2026-07-21T11:43:12","modified_gmt":"2026-07-21T11:43:12","slug":"drug-candidate-treats-severe-fatty-liver-disease-by-restoring-gut-barrier-integrity","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/drug-candidate-treats-severe-fatty-liver-disease-by-restoring-gut-barrier-integrity\/","title":{"rendered":"Drug Candidate Treats Severe Fatty Liver Disease by Restoring Gut Barrier Integrity"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"172982\" class=\"elementor elementor-172982\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2c08d e-con e-atomic-element e-flexbox-base e-d693f31 \" data-id=\"7b2c08d\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"7b2c08d\" data-e-type=\"e-flexbox\" data-id=\"7b2c08d\">\n    \t\t<div class=\"elementor-element elementor-element-b12c334 elementor-widget elementor-widget-text-editor\" data-id=\"b12c334\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A potential new treatment for metabolic dysfunction-associated steatohepatitis (MASH) works by improving gut health rather than targeting the liver directly, according to research published in <em>The Journal of Clinical Investigation<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f241f77 elementor-widget elementor-widget-text-editor\" data-id=\"f241f77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Researchers at Michigan Medicine found that the glycine-based tripeptide DT-109 reversed MASH in animal models by disrupting a disease-driving pathway linking the gut and liver. MASH affects approximately 7% of the global population and can progress to cirrhosis, liver cancer, and liver failure. Treatment options remain limited despite recent therapeutic advances.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bcdb794 elementor-widget elementor-widget-text-editor\" data-id=\"bcdb794\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The study identified a key driver of MASH: the proliferation of the bacterium Clostridium perfringens, which produces ammonia in the gut. Elevated ammonia levels erode the digestive tract&#8217;s inner lining and weaken the intestinal barrier, allowing harmful toxins to reach the liver and trigger inflammatory immune responses.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65630bd elementor-widget elementor-widget-text-editor\" data-id=\"65630bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"font-claude-response-body break-words whitespace-normal\">Through experiments in mice and non-human primates, the research team found that DT-109 interrupted this process. The compound diminished Clostridium perfringens populations and reduced intestinal ammonia production, strengthening the intestinal barrier. In non-human primates, whose livers and gut microbiota more closely resemble those of humans, DT-109 reduced liver inflammation and MASH severity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9f354e elementor-widget elementor-widget-text-editor\" data-id=\"d9f354e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Senior author Dr Eugene Chen noted clear evidence that DT-109 protects the gut epithelial barrier, reducing the systemic influx of harmful microbial products thought to contribute to MASH development and progression.<\/p>\n<p>The researchers suggest DT-109&#8217;s benefits may extend beyond MASH. Previous studies have shown the compound can limit atherosclerosis plaque formation and vascular calcification, positioning it as a potential treatment for cardiovascular disease. Because intestinal barrier dysfunction is implicated in several gastrointestinal disorders, the team believes DT-109 could eventually have applications in conditions such as inflammatory bowel disease.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb5aaf1 elementor-widget elementor-widget-text-editor\" data-id=\"bb5aaf1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Source: News Medical \/ University of Michigan (Journal of Clinical Investigation, 2026)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Severe fatty liver disease may be eased as MASH treatment improves gut health, offering a promising new approach beyond the liver.<\/p>\n","protected":false},"author":11,"featured_media":173009,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3200],"tags":[],"class_list":["post-172982","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Drug Candidate Treats Severe Fatty Liver Disease by Restoring Gut Barrier Integrity<\/title>\n<meta name=\"description\" content=\"Severe fatty liver disease may be eased as MASH treatment improves gut health, offering a promising new approach beyond the liver.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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