{"id":172050,"date":"2026-07-06T11:03:48","date_gmt":"2026-07-06T11:03:48","guid":{"rendered":"https:\/\/www.m3globalresearch.com\/blog\/?p=172050"},"modified":"2026-07-06T12:55:32","modified_gmt":"2026-07-06T12:55:32","slug":"sglt2-inhibitors-linked-to-lower-dementia-risk-in-adults-with-psychiatric-disorders","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/sglt2-inhibitors-linked-to-lower-dementia-risk-in-adults-with-psychiatric-disorders\/","title":{"rendered":"SGLT2 Inhibitors Linked to Lower Dementia Risk in Adults With Psychiatric Disorders"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"172050\" class=\"elementor elementor-172050\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2c08d e-con e-atomic-element e-flexbox-base e-d693f31 \" data-id=\"7b2c08d\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"7b2c08d\" data-e-type=\"e-flexbox\" data-id=\"7b2c08d\">\n    \t\t<div class=\"elementor-element elementor-element-fac4392 elementor-widget elementor-widget-text-editor\" data-id=\"fac4392\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Use of SGLT2 inhibitors was associated with reduced dementia incidence and fewer psychiatric emergency department visits in older adults with mood and psychotic disorders, according to a target trial emulation study published in <em>JAMA Network Open<\/em>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b12c334 elementor-widget elementor-widget-text-editor\" data-id=\"b12c334\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Researchers analysed data from the US Department of Veterans Affairs healthcare system covering 2016 to 2024, identifying 112,725 people aged 65 and older with major depressive disorder, bipolar disorder, or schizophrenia spectrum disorder. Participants had a median age of 74.1 years, with 6.8% having SGLT2 inhibitor exposure. Over a median follow-up of 3.3 years, 4.1% developed dementia.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f241f77 elementor-widget elementor-widget-text-editor\" data-id=\"f241f77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In an intention-to-treat analysis, patients using SGLT2 inhibitors were less likely to develop all-cause dementia (OR 0.61) and had fewer psychiatric emergency department visits (OR 0.80) compared with non-users. A per-protocol analysis showed SGLT2 inhibitor use was associated with lower odds of dementia (OR 0.54) and psychiatric hospitalisations (OR 0.56).<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bcdb794 elementor-widget elementor-widget-text-editor\" data-id=\"bcdb794\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Lead author Jaime Ramos-Cejudo of New York University Grossman School of Medicine noted that whilst SGLT2 inhibitors were developed for diabetes treatment, evidence suggests they may influence biological pathways involved in neurodegeneration, including brain energy metabolism, mitochondrial function, and inflammation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65630bd elementor-widget elementor-widget-text-editor\" data-id=\"65630bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The researchers highlighted that SGLT2 inhibitors are unique among antidiabetic medications in inducing ketogenesis. Ketogenic diets have shown preliminary associations with symptomatic improvement in psychiatric disorders, suggesting these medications may offer similar benefits pharmacologically.<\/p>\n<p>People with major depression, bipolar disorder, or schizophrenia have substantially increased dementia risk yet remain underrepresented in prevention research. The researchers acknowledged limitations including potential residual confounding and the predominantly male study population, which may limit generalisability.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb5aaf1 elementor-widget elementor-widget-text-editor\" data-id=\"bb5aaf1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Source: MedPage Today \/ JAMA Network Open (2026)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>SGLT2 inhibitors were linked to lower dementia risk and fewer emergency visits among older adults with psychiatric disorders.<\/p>\n","protected":false},"author":11,"featured_media":172256,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3200],"tags":[],"class_list":["post-172050","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.9 (Yoast SEO v27.9) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>SGLT2 Inhibitors Linked to Lower Dementia Risk in Adults With Psychiatric Disorders<\/title>\n<meta name=\"description\" content=\"SGLT2 inhibitors were linked to lower dementia risk and fewer emergency visits among older adults with psychiatric disorders.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, 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