{"id":171504,"date":"2026-06-21T20:47:09","date_gmt":"2026-06-21T20:47:09","guid":{"rendered":"https:\/\/www.m3globalresearch.com\/blog\/?p=171504"},"modified":"2026-06-22T10:02:10","modified_gmt":"2026-06-22T10:02:10","slug":"large-scale-genetic-study-identifies-new-risk-factors-for-pregnancy-related-liver-disease","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/large-scale-genetic-study-identifies-new-risk-factors-for-pregnancy-related-liver-disease\/","title":{"rendered":"Large-Scale Genetic Study Identifies New Risk Factors for Pregnancy-Related Liver Disease"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"171504\" class=\"elementor elementor-171504\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7b2c08d e-con e-atomic-element e-flexbox-base e-d693f31 \" data-id=\"7b2c08d\" data-element_type=\"e-flexbox\" data-e-type=\"e-flexbox\" data-interaction-id=\"7b2c08d\" data-e-type=\"e-flexbox\" data-id=\"7b2c08d\">\n    \t\t<div class=\"elementor-element elementor-element-fac4392 elementor-widget elementor-widget-text-editor\" data-id=\"fac4392\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A large international genome-wide meta-analysis has identified 26 genetic regions associated with intrahepatic cholestasis of pregnancy (ICP), including 10 not previously reported, providing new insight into the metabolic mechanisms underlying the condition. The findings are published in Nature Communications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b12c334 elementor-widget elementor-widget-text-editor\" data-id=\"b12c334\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>ICP affects approximately 0.2 to 2% of pregnant women and typically develops after 30 weeks of gestation. The condition is most commonly identified through severe pruritus of the palms and soles, with diagnosis confirmed by elevated liver enzymes and increased serum bile acid concentrations. Although ICP generally resolves following delivery, it is associated with an increased risk of preterm birth and stillbirth.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f241f77 elementor-widget elementor-widget-text-editor\" data-id=\"f241f77\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The study combined genetic data from more than 4,700 women with a history of ICP and a control group of over 436,000 women across Finland, Iceland, Estonia, and Denmark. The identified genetic regions involve genes regulating hepatic bile acid, lipid, and cholesterol processing, supporting the hypothesis that ICP results from a disruption in liver metabolism triggered by pregnancy-related hormonal changes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bcdb794 elementor-widget elementor-widget-text-editor\" data-id=\"bcdb794\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The researchers also examined broader disease associations linked to ICP. Women with a history of the condition showed an increased risk of hepatobiliary disorders, including fatty liver disease, gallstones, and cholangitis, as well as certain autoimmune conditions such as Crohn&#8217;s disease, thyroid disorders, and type 2 diabetes. Analyses further suggested a possible shared genetic basis between ICP and pancreatitis, a previously unreported association that the authors say warrants further investigation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65630bd elementor-widget elementor-widget-text-editor\" data-id=\"65630bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"font-claude-response-body break-words whitespace-normal\">The authors suggest these findings may support improved identification of at-risk individuals and inform earlier diagnosis of related metabolic and autoimmune conditions in women with a history of ICP.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bb5aaf1 elementor-widget elementor-widget-text-editor\" data-id=\"bb5aaf1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Source: Tyrmi JS et al. Genome-wide meta-analysis identifies genetic drivers of bile acid metabolism in intrahepatic cholestasis of pregnancy. Nature Communications (2026). DOI: 10.1038\/s41467-026-73122-z<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\n<\/div>\n\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Large-Scale Genetic Study Identifies New Risk Factors for Pregnancy-Related Liver Disease<\/p>\n","protected":false},"author":11,"featured_media":171537,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[3200],"tags":[],"class_list":["post-171504","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.7) - 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