{"id":169149,"date":"2026-04-13T16:03:03","date_gmt":"2026-04-13T15:03:03","guid":{"rendered":"https:\/\/m3globalresearch.blog\/?p=169149"},"modified":"2026-04-13T16:03:03","modified_gmt":"2026-04-13T15:03:03","slug":"study-reveals-lung-brain-communication-pathway","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/study-reveals-lung-brain-communication-pathway\/","title":{"rendered":"Study Reveals Lung-Brain Communication Pathway Linking Smoking and Dementia Risk","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"169149\" class=\"elementor elementor-169149\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0e02a2c e-flex e-con-boxed e-con e-parent\" data-id=\"0e02a2c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-225f5d2 elementor-widget elementor-widget-text-editor\" data-id=\"225f5d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\tResearch from the University of Chicago has identified a previously unmapped communication route between the lungs and brain that may help explain why heavy smoking in midlife is associated with increased dementia risk. The findings were published in <em>Science Advances<\/em>\n<br><br>\nPrevious studies have shown that heavy midlife smoking is associated with more than double the risk of dementia, Alzheimer&#8217;s disease, and vascular dementia decades later. Whilst most theories focus on smoking&#8217;s impact on the vascular and respiratory systems, the new research suggests nicotine-triggered signalling between the lungs and brain may also be involved.\n<br><br>\nThe study focused on pulmonary neuroendocrine cells (PNECs), rare lung cells that combine functions of both nerve and endocrine cells. When exposed to nicotine, these cells release large quantities of exosomes, tiny particles containing biological material, that are rich in serotransferrin, a protein involved in iron regulation.\n<br><br>\nResearchers generated induced PNECs from human pluripotent stem cells to study these cells, which comprise less than 1% of lung tissue. They found that nicotine exposure caused PNECs to release massive amounts of serotransferrin-rich exosomes, disrupting iron balance in neurons.\n<br><br>\nAccording to the corresponding author, Assistant Professor Joyce Chen, this iron imbalance drives oxidative stress, mitochondrial dysfunction, and increased \u03b1-synuclein expression\u2014hallmarks of neurodegenerative disease. The disruption can also wrongly trigger ferroptosis, a form of programmed cell death previously associated with both Alzheimer&#8217;s and Parkinson&#8217;s disease.\n<br><br>\nThe research establishes a clear lung-brain axis, revealing the lung as an active signalling organ rather than merely a passive target of smoke exposure. The team is now investigating whether blocking these exosomes could have therapeutic applications for preventing neurodegeneration.\n<br><br>\n<strong>Source:<\/strong> Medical Xpress \/ University of Chicago (Science Advances, 2026)\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bd3d138 e-con-full e-flex e-con e-child\" data-id=\"bd3d138\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2708250 elementor-share-buttons--view-icon elementor-share-buttons--skin-minimal elementor-share-buttons--shape-circle elementor-share-buttons--color-custom elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"2708250\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div 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1.8-3.7.9-6.9-.5-9.7-1.4-2.8-12.5-30.1-17.1-41.2-4.5-10.8-9.1-9.3-12.5-9.5-3.2-.2-6.9-.2-10.6-.2-3.7 0-9.7 1.4-14.8 6.9-5.1 5.6-19.4 19-19.4 46.3 0 27.3 19.9 53.7 22.6 57.4 2.8 3.7 39.1 59.7 94.8 83.8 35.2 15.2 49 16.5 66.6 13.9 10.7-1.6 32.8-13.4 37.4-26.4 4.6-13 4.6-24.1 3.2-26.4-1.3-2.5-5-3.9-10.5-6.6z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_facebook\" role=\"button\" tabindex=\"0\" aria-label=\"Share on facebook\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-facebook\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.78 90.69 226.38 209.25 245V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.31 482.38 504 379.78 504 256z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_twitter\" role=\"button\" tabindex=\"0\" aria-label=\"Share on twitter\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-twitter\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M459.37 151.716c.325 4.548.325 9.097.325 13.645 0 138.72-105.583 298.558-298.558 298.558-59.452 0-114.68-17.219-161.137-47.106 8.447.974 16.568 1.299 25.34 1.299 49.055 0 94.213-16.568 130.274-44.832-46.132-.975-84.792-31.188-98.112-72.772 6.498.974 12.995 1.624 19.818 1.624 9.421 0 18.843-1.3 27.614-3.573-48.081-9.747-84.143-51.98-84.143-102.985v-1.299c13.969 7.797 30.214 12.67 47.431 13.319-28.264-18.843-46.781-51.005-46.781-87.391 0-19.492 5.197-37.36 14.294-52.954 51.655 63.675 129.3 105.258 216.365 109.807-1.624-7.797-2.599-15.918-2.599-24.04 0-57.828 46.782-104.934 104.934-104.934 30.213 0 57.502 12.67 76.67 33.137 23.715-4.548 46.456-13.32 66.599-25.34-7.798 24.366-24.366 44.833-46.132 57.827 21.117-2.273 41.584-8.122 60.426-16.243-14.292 20.791-32.161 39.308-52.628 54.253z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8a64235 e-flex e-con-boxed e-con e-parent\" data-id=\"8a64235\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-bbd8503 elementor-widget 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science advances reveals<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":169237,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3200],"tags":[3793,3623],"class_list":["post-169149","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news","tag-dementia","tag-neurology"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Study Reveals Lung-Brain Communication Pathway Linking Smoking and Dementia Risk<\/title>\n<meta name=\"description\" content=\"Smoking and dementia risk linked to unmapped communication route between lungs and brain, new research in Science Advances reveals\" \/>\n<meta name=\"robots\" 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