{"id":168887,"date":"2026-04-07T10:11:06","date_gmt":"2026-04-07T09:11:06","guid":{"rendered":"https:\/\/m3globalresearch.blog\/?p=168887"},"modified":"2026-04-07T10:11:06","modified_gmt":"2026-04-07T09:11:06","slug":"novel-eye-drop-delivery-system-shows-promise-childhood-eye-cancer-treatment","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/novel-eye-drop-delivery-system-shows-promise-childhood-eye-cancer-treatment\/","title":{"rendered":"Novel Eye Drop Delivery System Shows Promise for Childhood Eye Cancer Treatment","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"168887\" class=\"elementor elementor-168887\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c363ba6 e-flex e-con-boxed e-con e-parent\" data-id=\"c363ba6\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ee50a10 elementor-widget elementor-widget-text-editor\" data-id=\"ee50a10\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Researchers have developed a non-invasive eye drop delivery system that could offer a safer and more effective treatment for retinoblastoma (RB), a form of eye cancer most commonly affecting children. The study was published in <em>Science Advances<\/em>.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Treating retinoblastoma requires penetrating the protective barrier surrounding the eye. Current methods, including injections, chemotherapy, and radiotherapy, are often painful and can cause vision loss and other serious side effects. The new approach uses tiny vesicles called exosomes derived from pig semen (SEVs), which have naturally evolved proteins that enable them to cross biological barriers.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The research team engineered eye drops combining SEVs with folic acid and a nanozyme system (CMG) composed of carbon dots, manganese dioxide, and glucose oxidase. The CMG system triggers oxidative stress in tumour cells, leading to their destruction whilst sparing healthy tissue. Folic acid helps target tumours, whilst SEVs temporarily and reversibly open tight junctions in the eye&#8217;s protective layers, enabling drug entry through both corneal and conjunctival pathways.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">In mouse models with eye tumours, mice treated with the eye drop system showed significant tumour reduction over 30 days compared to untreated animals and those receiving alternative treatments. The treated group retained only approximately 2.35% of residual tumour mass after 30 days and maintained near-normal eye clarity, whilst untreated mice developed severe abnormal blood vessel growth and opacity.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The researchers noted the method avoids potential structural damage and systemic toxicity associated with existing delivery approaches. The platform may also prove useful for other ocular conditions, including age-related macular degeneration and diabetic retinopathy. Further development is required before human trials, including addressing manufacturing standardisation and safety considerations.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><strong>Source:<\/strong> Medical Xpress \/ Science Advances (2026)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-260c2c0 e-con-full e-flex e-con e-child\" data-id=\"260c2c0\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-cbb62f3 elementor-share-buttons--view-icon elementor-share-buttons--skin-minimal elementor-share-buttons--shape-circle elementor-share-buttons--color-custom elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"cbb62f3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" 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