{"id":168699,"date":"2026-03-31T15:09:45","date_gmt":"2026-03-31T14:09:45","guid":{"rendered":"https:\/\/m3globalresearch.blog\/?p=168699"},"modified":"2026-03-31T15:09:45","modified_gmt":"2026-03-31T14:09:45","slug":"protein-discovery-reveals-natural-brake-against-sepsis-overreaction","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/","title":{"rendered":"Protein Discovery Reveals Natural &#8216;Brake&#8217; Against Sepsis Overreaction","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"168699\" class=\"elementor elementor-168699\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31cca3b e-flex e-con-boxed e-con e-parent\" data-id=\"31cca3b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6dc03d0 elementor-widget elementor-widget-text-editor\" data-id=\"6dc03d0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Scientists have identified a protein that acts as a natural regulator to prevent the immune system from causing excessive damage during severe infections. The discovery, published in <em>Redox Biology<\/em>, could lead to new treatments for sepsis, one of the leading causes of hospital deaths worldwide.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Researchers at National Taiwan University found that the protein PP4 works inside immune cells, particularly macrophages and neutrophils, to control inflammatory responses. In healthy conditions, PP4 prevents macrophages from releasing excessive amounts of a signalling molecule called CCL5. When PP4 levels are insufficient, CCL5 binds to neutrophil receptors and triggers them to produce sticky, web-like structures known as neutrophil extracellular traps (NETs). Whilst NETs normally help capture bacteria, overproduction leads to additional inflammation, harmful chemical release, and organ damage.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">To investigate, the team created mice lacking PP4 only in immune cells. When exposed to conditions mimicking severe infection, these mice became significantly more unwell, with greater tissue damage and higher mortality compared to normal mice. The absence of PP4 resulted in uncontrolled signalling between macrophages and neutrophils, excessive NET formation, and the release of tissue-destroying enzymes.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The researchers found that blocking CCL5 receptors on neutrophils reduced the overreaction and associated damage. In laboratory tests, restoring functional PP4, but not a mutated version, successfully lowered harmful signals and prevented excessive NET production.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The findings help explain why some patients develop fatal sepsis whilst others recover, with PP4 balance appearing central to whether the immune response protects or harms the body. Because PP4 limits excessive inflammation without completely suppressing immunity, it represents a promising therapeutic target for future sepsis treatments.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><strong>Source:<\/strong> Medical Xpress \/ National Taiwan University (Redox Biology, 2026)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7775497 e-con-full e-flex e-con e-child\" data-id=\"7775497\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-789d44d elementor-share-buttons--view-icon elementor-share-buttons--skin-minimal elementor-share-buttons--shape-circle elementor-share-buttons--color-custom elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"789d44d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_email\" role=\"button\" tabindex=\"0\" aria-label=\"Share on email\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-envelope\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M502.3 190.8c3.9-3.1 9.7-.2 9.7 4.7V400c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V195.6c0-5 5.7-7.8 9.7-4.7 22.4 17.4 52.1 39.5 154.1 113.6 21.1 15.4 56.7 47.8 92.2 47.6 35.7.3 72-32.8 92.3-47.6 102-74.1 131.6-96.3 154-113.7zM256 320c23.2.4 56.6-29.2 73.4-41.4 132.7-96.3 142.8-104.7 173.4-128.7 5.8-4.5 9.2-11.5 9.2-18.9v-19c0-26.5-21.5-48-48-48H48C21.5 64 0 85.5 0 112v19c0 7.4 3.4 14.3 9.2 18.9 30.6 23.9 40.7 32.4 173.4 128.7 16.8 12.2 50.2 41.8 73.4 41.4z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_linkedin\" role=\"button\" tabindex=\"0\" aria-label=\"Share on linkedin\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-linkedin\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 32-32.3V64.3c0-17.8-14.4-32.3-32-32.3zM135.4 416H69V202.2h66.5V416zm-33.2-243c-21.3 0-38.5-17.3-38.5-38.5S80.9 96 102.2 96c21.2 0 38.5 17.3 38.5 38.5 0 21.3-17.2 38.5-38.5 38.5zm282.1 243h-66.4V312c0-24.8-.5-56.7-34.5-56.7-34.6 0-39.9 27-39.9 54.9V416h-66.4V202.2h63.7v29.2h.9c8.9-16.8 30.6-34.5 62.9-34.5 67.2 0 79.7 44.3 79.7 101.9V416z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_whatsapp\" role=\"button\" tabindex=\"0\" aria-label=\"Share on whatsapp\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-whatsapp\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M380.9 97.1C339 55.1 283.2 32 223.9 32c-122.4 0-222 99.6-222 222 0 39.1 10.2 77.3 29.6 111L0 480l117.7-30.9c32.4 17.7 68.9 27 106.1 27h.1c122.3 0 224.1-99.6 224.1-222 0-59.3-25.2-115-67.1-157zm-157 341.6c-33.2 0-65.7-8.9-94-25.7l-6.7-4-69.8 18.3L72 359.2l-4.4-7c-18.5-29.4-28.2-63.3-28.2-98.2 0-101.7 82.8-184.5 184.6-184.5 49.3 0 95.6 19.2 130.4 54.1 34.8 34.9 56.2 81.2 56.1 130.5 0 101.8-84.9 184.6-186.6 184.6zm101.2-138.2c-5.5-2.8-32.8-16.2-37.9-18-5.1-1.9-8.8-2.8-12.5 2.8-3.7 5.6-14.3 18-17.6 21.8-3.2 3.7-6.5 4.2-12 1.4-32.6-16.3-54-29.1-75.5-66-5.7-9.8 5.7-9.1 16.3-30.3 1.8-3.7.9-6.9-.5-9.7-1.4-2.8-12.5-30.1-17.1-41.2-4.5-10.8-9.1-9.3-12.5-9.5-3.2-.2-6.9-.2-10.6-.2-3.7 0-9.7 1.4-14.8 6.9-5.1 5.6-19.4 19-19.4 46.3 0 27.3 19.9 53.7 22.6 57.4 2.8 3.7 39.1 59.7 94.8 83.8 35.2 15.2 49 16.5 66.6 13.9 10.7-1.6 32.8-13.4 37.4-26.4 4.6-13 4.6-24.1 3.2-26.4-1.3-2.5-5-3.9-10.5-6.6z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_facebook\" role=\"button\" tabindex=\"0\" aria-label=\"Share on facebook\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-facebook\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M504 256C504 119 393 8 256 8S8 119 8 256c0 123.78 90.69 226.38 209.25 245V327.69h-63V256h63v-54.64c0-62.15 37-96.48 93.67-96.48 27.14 0 55.52 4.84 55.52 4.84v61h-31.28c-30.8 0-40.41 19.12-40.41 38.73V256h68.78l-11 71.69h-57.78V501C413.31 482.38 504 379.78 504 256z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_twitter\" role=\"button\" tabindex=\"0\" aria-label=\"Share on twitter\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-twitter\" viewBox=\"0 0 512 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M459.37 151.716c.325 4.548.325 9.097.325 13.645 0 138.72-105.583 298.558-298.558 298.558-59.452 0-114.68-17.219-161.137-47.106 8.447.974 16.568 1.299 25.34 1.299 49.055 0 94.213-16.568 130.274-44.832-46.132-.975-84.792-31.188-98.112-72.772 6.498.974 12.995 1.624 19.818 1.624 9.421 0 18.843-1.3 27.614-3.573-48.081-9.747-84.143-51.98-84.143-102.985v-1.299c13.969 7.797 30.214 12.67 47.431 13.319-28.264-18.843-46.781-51.005-46.781-87.391 0-19.492 5.197-37.36 14.294-52.954 51.655 63.675 129.3 105.258 216.365 109.807-1.624-7.797-2.599-15.918-2.599-24.04 0-57.828 46.782-104.934 104.934-104.934 30.213 0 57.502 12.67 76.67 33.137 23.715-4.548 46.456-13.32 66.599-25.34-7.798 24.366-24.366 44.833-46.132 57.827 21.117-2.273 41.584-8.122 60.426-16.243-14.292 20.791-32.161 39.308-52.628 54.253z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ba045d2 e-flex e-con-boxed e-con e-parent\" data-id=\"ba045d2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e81ff85 elementor-widget elementor-widget-spacer\" data-id=\"e81ff85\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e498b61 e-con-full e-flex e-con e-child\" data-id=\"e498b61\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8c6bfad elementor-widget elementor-widget-heading\" data-id=\"8c6bfad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Participate in Paid Infectious Diseases Surveys\n<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca1412c elementor-widget elementor-widget-spacer\" data-id=\"ca1412c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-233ac3c e-flex e-con-boxed e-con e-parent\" data-id=\"233ac3c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fa5b388 e-con-full e-flex e-con e-child\" data-id=\"fa5b388\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ddccc13 e-con-full e-flex e-con e-child\" data-id=\"ddccc13\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8469893 elementor-align-center elementor-mobile-align-center elementor-widget elementor-widget-button\" data-id=\"8469893\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm elementor-animation-grow\" href=\"https:\/\/m3globalresearch.blog\/medical-news\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Latest Medical News<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cf8157a e-con-full e-flex e-con e-child\" data-id=\"cf8157a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis.<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":168790,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3200],"tags":[3605,8282],"class_list":["post-168699","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news","tag-infectious-diseases","tag-sepsis"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Protein Discovery Reveals Natural &#039;Brake&#039; Against Sepsis Overreaction<\/title>\n<meta name=\"description\" content=\"Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protein Discovery Reveals Natural &#039;Brake&#039; Against Sepsis Overreaction\" \/>\n<meta property=\"og:description\" content=\"Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/\" \/>\n<meta property=\"og:site_name\" content=\"M3 Global Research\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/en-gb.facebook.com\/M3GlobalResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2026-03-31T14:09:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/03\/sepsis-overreaction-1024x683.jpeg\" \/>\n\t<meta property=\"og:image:width\" content=\"1024\" \/>\n\t<meta property=\"og:image:height\" content=\"683\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"m3gr-blog-admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@M3GR_Community\" \/>\n<meta name=\"twitter:site\" content=\"@M3GR_Community\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"m3gr-blog-admin\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/\"},\"author\":{\"name\":\"m3gr-blog-admin\",\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#\\\/schema\\\/person\\\/11bace963d7a45380011c4911a822a6c\"},\"headline\":\"Protein Discovery Reveals Natural &#8216;Brake&#8217; Against Sepsis Overreaction\",\"datePublished\":\"2026-03-31T14:09:45+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/\"},\"wordCount\":293,\"commentCount\":0,\"publisher\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/sepsis-overreaction-scaled.jpeg\",\"keywords\":[\"infectious diseases\",\"sepsis\"],\"articleSection\":[\"Latest Medical News\"],\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/#respond\"]}]},{\"@type\":[\"WebPage\",\"MedicalWebPage\"],\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/\",\"url\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/\",\"name\":\"Protein Discovery Reveals Natural 'Brake' Against Sepsis Overreaction\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/sepsis-overreaction-scaled.jpeg\",\"datePublished\":\"2026-03-31T14:09:45+00:00\",\"description\":\"Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/sepsis-overreaction-scaled.jpeg\",\"contentUrl\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/wp-content\\\/uploads\\\/2026\\\/03\\\/sepsis-overreaction-scaled.jpeg\",\"width\":7952,\"height\":5304,\"caption\":\"Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis.\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Protein Discovery Reveals Natural &#8216;Brake&#8217; Against Sepsis Overreaction\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/\",\"name\":\"M3 Global Research\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#organization\",\"name\":\"M3 Global Research\",\"url\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":null,\"contentUrl\":null,\"width\":null,\"height\":null,\"caption\":\"M3 Global Research\"},\"image\":{\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/en-gb.facebook.com\\\/M3GlobalResearch\\\/\",\"https:\\\/\\\/x.com\\\/M3GR_Community\",\"https:\\\/\\\/www.instagram.com\\\/m3globalresearch\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/10557915\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/#\\\/schema\\\/person\\\/11bace963d7a45380011c4911a822a6c\",\"name\":\"m3gr-blog-admin\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb0c444d9d8b383c405133f87af6215220f0327b7f797aec37db4ab6b6b18364?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb0c444d9d8b383c405133f87af6215220f0327b7f797aec37db4ab6b6b18364?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/fb0c444d9d8b383c405133f87af6215220f0327b7f797aec37db4ab6b6b18364?s=96&d=mm&r=g\",\"caption\":\"m3gr-blog-admin\"},\"sameAs\":[\"https:\\\/\\\/blog.m3globalresearch.com\"],\"url\":\"https:\\\/\\\/www.m3globalresearch.com\\\/blog\\\/author\\\/m3gr-blog-admin\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Protein Discovery Reveals Natural 'Brake' Against Sepsis Overreaction","description":"Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/","og_locale":"en_US","og_type":"article","og_title":"Protein Discovery Reveals Natural 'Brake' Against Sepsis Overreaction","og_description":"Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis.","og_url":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/","og_site_name":"M3 Global Research","article_publisher":"https:\/\/en-gb.facebook.com\/M3GlobalResearch\/","article_published_time":"2026-03-31T14:09:45+00:00","og_image":[{"width":1024,"height":683,"url":"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/03\/sepsis-overreaction-1024x683.jpeg","type":"image\/jpeg"}],"author":"m3gr-blog-admin","twitter_card":"summary_large_image","twitter_creator":"@M3GR_Community","twitter_site":"@M3GR_Community","twitter_misc":{"Written by":"m3gr-blog-admin","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/#article","isPartOf":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/"},"author":{"name":"m3gr-blog-admin","@id":"https:\/\/www.m3globalresearch.com\/blog\/#\/schema\/person\/11bace963d7a45380011c4911a822a6c"},"headline":"Protein Discovery Reveals Natural &#8216;Brake&#8217; Against Sepsis Overreaction","datePublished":"2026-03-31T14:09:45+00:00","mainEntityOfPage":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/"},"wordCount":293,"commentCount":0,"publisher":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/#primaryimage"},"thumbnailUrl":"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/03\/sepsis-overreaction-scaled.jpeg","keywords":["infectious diseases","sepsis"],"articleSection":["Latest Medical News"],"inLanguage":"en-US","potentialAction":[{"@type":"CommentAction","name":"Comment","target":["https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/#respond"]}]},{"@type":["WebPage","MedicalWebPage"],"@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/","url":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/","name":"Protein Discovery Reveals Natural 'Brake' Against Sepsis Overreaction","isPartOf":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/#primaryimage"},"image":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/#primaryimage"},"thumbnailUrl":"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/03\/sepsis-overreaction-scaled.jpeg","datePublished":"2026-03-31T14:09:45+00:00","description":"Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis.","breadcrumb":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/#primaryimage","url":"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/03\/sepsis-overreaction-scaled.jpeg","contentUrl":"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/03\/sepsis-overreaction-scaled.jpeg","width":7952,"height":5304,"caption":"Redox Biology study identifies PP4 protein in sepsis, helping control sepsis overreaction and guiding new treatments for sepsis."},{"@type":"BreadcrumbList","@id":"https:\/\/www.m3globalresearch.com\/blog\/protein-discovery-reveals-natural-brake-against-sepsis-overreaction\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.m3globalresearch.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Protein Discovery Reveals Natural &#8216;Brake&#8217; Against Sepsis Overreaction"}]},{"@type":"WebSite","@id":"https:\/\/www.m3globalresearch.com\/blog\/#website","url":"https:\/\/www.m3globalresearch.com\/blog\/","name":"M3 Global Research","description":"","publisher":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.m3globalresearch.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.m3globalresearch.com\/blog\/#organization","name":"M3 Global Research","url":"https:\/\/www.m3globalresearch.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.m3globalresearch.com\/blog\/#\/schema\/logo\/image\/","url":null,"contentUrl":null,"width":null,"height":null,"caption":"M3 Global Research"},"image":{"@id":"https:\/\/www.m3globalresearch.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/en-gb.facebook.com\/M3GlobalResearch\/","https:\/\/x.com\/M3GR_Community","https:\/\/www.instagram.com\/m3globalresearch","https:\/\/www.linkedin.com\/company\/10557915"]},{"@type":"Person","@id":"https:\/\/www.m3globalresearch.com\/blog\/#\/schema\/person\/11bace963d7a45380011c4911a822a6c","name":"m3gr-blog-admin","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/fb0c444d9d8b383c405133f87af6215220f0327b7f797aec37db4ab6b6b18364?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/fb0c444d9d8b383c405133f87af6215220f0327b7f797aec37db4ab6b6b18364?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/fb0c444d9d8b383c405133f87af6215220f0327b7f797aec37db4ab6b6b18364?s=96&d=mm&r=g","caption":"m3gr-blog-admin"},"sameAs":["https:\/\/blog.m3globalresearch.com"],"url":"https:\/\/www.m3globalresearch.com\/blog\/author\/m3gr-blog-admin\/"}]}},"jetpack_featured_media_url":"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/03\/sepsis-overreaction-scaled.jpeg","jetpack_sharing_enabled":true,"gt_translate_keys":[{"key":"link","format":"url"}],"_links":{"self":[{"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/posts\/168699","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/comments?post=168699"}],"version-history":[{"count":0,"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/posts\/168699\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/media\/168790"}],"wp:attachment":[{"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/media?parent=168699"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/categories?post=168699"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.m3globalresearch.com\/blog\/wp-json\/wp\/v2\/tags?post=168699"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}