{"id":168693,"date":"2026-03-31T15:09:29","date_gmt":"2026-03-31T14:09:29","guid":{"rendered":"https:\/\/m3globalresearch.blog\/?p=168693"},"modified":"2026-03-31T15:09:29","modified_gmt":"2026-03-31T14:09:29","slug":"peptide-technology-could-enable-oral-insulin-pills","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/peptide-technology-could-enable-oral-insulin-pills\/","title":{"rendered":"Peptide Technology Could Enable Oral Insulin Pills for Diabetes","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"168693\" class=\"elementor elementor-168693\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-07ae306 e-flex e-con-boxed e-con e-parent\" data-id=\"07ae306\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0567de1 elementor-widget elementor-widget-text-editor\" data-id=\"0567de1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">Researchers at Kumamoto University have developed a peptide-based technology platform that may allow insulin to be taken orally, potentially replacing daily injections for millions of diabetes patients. The findings were published in <em>Molecular Pharmaceutics<\/em>.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">For over a century, scientists have pursued oral insulin delivery, but the digestive system breaks down the hormone before it can reach the bloodstream, and the intestine lacks a natural absorption mechanism. The new approach uses a cyclic peptide called DNP that can pass through the small intestine, enabling oral insulin delivery.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The research team, led by Associate Professor Shingo Ito, tested two methods. The first involved mixing a modified D-DNP-V peptide with zinc-stabilised insulin hexamers. When administered orally to diabetic mouse models, this mixture rapidly normalised blood glucose levels, with stable control maintained through once-daily dosing over three consecutive days. The second method used click chemistry to attach the DNP peptide directly to insulin, creating a conjugate that proved equally effective.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">A significant barrier to oral insulin has been the requirement for extremely high doses compared to injections. The new platform achieved pharmacological bioavailability of approximately 33\u201341% relative to subcutaneous injection, substantially reducing the dose needed and making oral administration more practical.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\">The researchers noted that their peptide-based platform may also be applicable to long-acting insulin formulations and other injectable biological therapies. Additional studies are planned, including testing in larger animal models and systems that replicate the human intestine, as the team works towards clinical applications.<\/p><p class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"><strong>Source:<\/strong> Science Daily \/ Kumamoto University (Molecular Pharmaceutics, 2026)<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6467793 e-con-full e-flex e-con e-child\" data-id=\"6467793\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c0e364a elementor-share-buttons--view-icon elementor-share-buttons--skin-minimal elementor-share-buttons--shape-circle elementor-share-buttons--color-custom elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"c0e364a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" 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