{"id":167748,"date":"2026-03-03T12:13:50","date_gmt":"2026-03-03T12:13:50","guid":{"rendered":"https:\/\/m3globalresearch.blog\/?p=167748"},"modified":"2026-03-03T12:13:50","modified_gmt":"2026-03-03T12:13:50","slug":"understanding-cancer-genes","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/understanding-cancer-genes\/","title":{"rendered":"Understanding Cancer Genes: How DNA Mutations Drive Cancer Development","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"167748\" class=\"elementor elementor-167748\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-575540b e-flex e-con-boxed e-con e-parent\" data-id=\"575540b\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f4ea01e elementor-widget elementor-widget-text-editor\" data-id=\"f4ea01e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Cancer arises from accumulated DNA mutations that disrupt the normal functioning of cells. An explainer published in <em>The Conversation<\/em> by researchers from the Walter and Eliza Hall Institute of Medical Research outlines how genetic changes contribute to cancer development and what inherited mutations mean for individual risk.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e86323 elementor-widget elementor-widget-text-editor\" data-id=\"7e86323\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>DNA contains instructions for producing proteins, molecules that carry out virtually every function within a cell. When a mutation occurs in a gene, the resulting protein may not work correctly. Cells have dedicated repair proteins to address such errors, but if the gene encoding a repair protein is itself mutated, subsequent DNA damage may go uncorrected. Over time, accumulated mutations can cause a cell to divide uncontrollably and evade normal cell death, the hallmarks of cancer.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4741827 elementor-widget elementor-widget-text-editor\" data-id=\"4741827\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Mutations can occur in two ways: in reproductive cells (germline), where they can be inherited by children, or in other cell types (somatic), where they affect only the individual. Germline mutations are of particular clinical significance because every cell in the body carries the affected gene from birth, increasing the overall likelihood of cancer-driving errors accumulating over a lifetime.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-51af151 elementor-widget elementor-widget-text-editor\" data-id=\"51af151\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Well-studied examples include the BRCA1 and BRCA2 genes, involved in DNA repair, and TP53, which normally triggers the destruction of abnormal cells. Inherited mutations in these genes are associated with meaningfully elevated cancer risk compared to the general population.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c68fcb7 elementor-widget elementor-widget-text-editor\" data-id=\"c68fcb7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>For individuals with a family history of cancer, clinical guidance recommends genetic testing and counselling, which may lead to earlier screening or other preventive measures. The authors note that while genetic risk cannot be modified, lifestyle factors, including avoiding smoking and alcohol, maintaining regular physical activity, and sun protection, may help reduce overall cancer risk.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fb06a2 elementor-widget elementor-widget-text-editor\" data-id=\"4fb06a2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Source: Medical Express \/ The Conversation<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3d68fb5 e-con-full e-flex e-con e-child\" data-id=\"3d68fb5\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t<div class=\"elementor-element elementor-element-2569fea elementor-share-buttons--view-icon elementor-share-buttons--skin-minimal elementor-share-buttons--shape-circle 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risk.<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":167752,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[3200],"tags":[],"class_list":["post-167748","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-latest-medical-news"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.7) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Understanding Cancer Genes: How DNA Mutations Drive Cancer Development<\/title>\n<meta name=\"description\" content=\"Explainer on understanding cancer genes shows how DNA mutations and genetic changes drive cancer development and inherited risk.\" \/>\n<meta name=\"robots\" content=\"index, follow, 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