{"id":160372,"date":"2025-01-15T09:09:07","date_gmt":"2025-01-15T09:09:07","guid":{"rendered":"https:\/\/m3globalresearch.blog\/?p=160372"},"modified":"2026-05-19T16:34:59","modified_gmt":"2026-05-19T16:34:59","slug":"difference-between-drug-repurposing-drug-repositioning-examples","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/difference-between-drug-repurposing-drug-repositioning-examples\/","title":{"rendered":"The Difference Between Drug Repurposing and Drug Repositioning with Examples","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"160372\" class=\"elementor elementor-160372\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c98ce8f e-con-full e-flex e-con e-parent\" data-id=\"c98ce8f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t<div class=\"elementor-element elementor-element-73b8ae8 e-con-full e-flex e-con e-child\" data-id=\"73b8ae8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0ada53c elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"0ada53c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p style=\"text-align: left;\"><strong>As a healthcare professional, it is important to understand the difference between \u201cdrug repurposing\u201d and \u201cdrug repositioning.\u201d The terms are often used interchangeably but can have different processes and regulatory implications in drug development. Here, you will learn about the differences between the two terms with real-world examples of repurposed drugs and repositioned drugs.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd75de4 elementor-widget elementor-widget-text-editor\" data-id=\"cd75de4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>What is the difference between \u201cdrug repurposing\u201d and \u201cdrug repositioning\u201d? While both processes aim to extend the utility of drugs, their specific focus, origins, and regulatory implications may differ. Because there are no officially approved definitions of these terms, they are often used interchangeably. This sometimes creates confusion, slows down processes, and hinders opportunities for collaboration in drug development and research.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6bde934 elementor-widget elementor-widget-text-editor\" data-id=\"6bde934\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>A <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25975957\/\">study<\/a> by researchers at Utrecht University found only about 31% of articles using the terms \u201cdrug repositioning\u201d and \u201cdrug repurposing\u201d provided a definition, leaving 69% without definition. The definitions provided ranged from brief to extensive, but no common definition was found, which often leads to differences in meaning. The study suggests that in cases where a clear definition is required, such as for legal or regulatory purposes, further clarification is needed.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b2e36b elementor-widget elementor-widget-text-editor\" data-id=\"2b2e36b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Although these two definitions differ, they both aim to utilise existing drugs in drug development, provide a cost- and time-efficient solution, and explore new therapeutic indications. Both processes can offer a quicker and more affordable path to treatment for unmet medical needs.\u00a0\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f7f2de4 elementor-widget elementor-widget-text-editor\" data-id=\"f7f2de4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Recently, using drug repurposing and repositioning as strategies has become more common as researchers focus on expanding the uses of existing drugs. Advances in artificial intelligence and big data analytics have significantly increased the speed and success of identifying new uses for existing drugs. However, unexpected repurposing can occur, particularly through clinical observations or unexpected findings during trials.\u00a0<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-39f7754 elementor-widget elementor-widget-text-editor\" data-id=\"39f7754\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Continue reading to gain a deeper understanding of the difference between drug repurposing and drug repositioning:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4d3c2e4 elementor-widget elementor-widget-text-editor\" data-id=\"4d3c2e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li><a href=\"#DrugRepurposing\">What is Drug Repurposing?<\/a><\/li><li><a href=\"#DrugRepositioning\">What is Drug Repositioning?<\/a><\/li><li><a href=\"#KeyBenefits\">Key Benefits of Drug Repurposing and Drug Repositioning<\/a><\/li><li><a href=\"#KeyRisks\">Key risks of Drug Repurposing and Drug Repositioning<\/a><\/li><li><a href=\"#Examplesofdrugrepurposing\">Examples of Drug Repurposing and Drug Repositioning<\/a><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1d8fb14 elementor-widget elementor-widget-text-editor\" data-id=\"1d8fb14\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><span class=\"TextRun SCXW128435776 BCX0\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW128435776 BCX0\">Did you find this article<\/span><span class=\"NormalTextRun SCXW128435776 BCX0\"> on <\/span><\/span><span class=\"TextRun Highlight SCXW128435776 BCX0\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW128435776 BCX0\">drug repurposing and repositioning<\/span><\/span><span class=\"TextRun SCXW128435776 BCX0\" lang=\"EN-GB\" xml:lang=\"EN-GB\" data-contrast=\"auto\"><span class=\"NormalTextRun SCXW128435776 BCX0\"> helpful? Make sure to leave your feedback in the <\/span><a href=\"#comments\"><span class=\"NormalTextRun CommentStart CommentHighlightPipeRestRefresh CommentHighlightRest SCXW128435776 BCX0\">comment section below<\/span><\/a> <span class=\"NormalTextRun CommentHighlightPipeRestRefresh SCXW128435776 BCX0\">to help us improve our content.<\/span><\/span><span class=\"EOP SCXW128435776 BCX0\" data-ccp-props=\"{}\">\u00a0<\/span><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-cd994cd elementor-widget elementor-widget-menu-anchor\" data-id=\"cd994cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"DrugRepurposing\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b39103c elementor-widget elementor-widget-spacer\" data-id=\"b39103c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c23683 elementor-widget elementor-widget-image\" data-id=\"6c23683\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2025\/01\/The-Difference-Between-Drug-Repurposing-and-Drug-Repositioning-with-Examples.jpg\" title=\"The Difference Between Drug Repurposing and Drug Repositioning with Examples\" alt=\"As a healthcare professional, it is important to understand the difference between \u201cdrug repurposing\u201d and \u201cdrug repositioning.\u201d The terms are often used interchangeably but can have different processes and regulatory implications in drug development. Here, you will learn about the differences between the two terms with real-world examples of repurposed drugs and repositioned drugs.\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c2d2a49 elementor-widget elementor-widget-spacer\" data-id=\"c2d2a49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4aa9b25 elementor-widget elementor-widget-heading\" data-id=\"4aa9b25\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">What is Drug Repurposing? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6c6e1ad elementor-widget elementor-widget-text-editor\" data-id=\"6c6e1ad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Drug repurposing often refers to identifying new therapeutic uses for drugs that have already been approved for specific conditions.<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9945820\/\" target=\"_blank\" rel=\"noopener\">*<\/a> These drugs have undergone rigorous testing for safety and efficacy, which reduces the time and resources needed to assess their potential for other diseases. By leveraging the established safety profiles of these drugs, repurposing offers a more efficient path to developing treatments for other indications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efa7e16 elementor-widget elementor-widget-text-editor\" data-id=\"efa7e16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This process accelerates the drug development timeline and reduces overall costs, as the drug has already passed extensive clinical trials and is familiar to regulatory bodies. As a result, repurposed drugs can often be brought to market more quickly, making them a valuable tool for addressing unmet or emerging medical needs.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eac06c5 elementor-widget elementor-widget-spacer\" data-id=\"eac06c5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f3d391 elementor-widget elementor-widget-menu-anchor\" data-id=\"8f3d391\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"DrugRepositioning\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-499e369 elementor-widget elementor-widget-heading\" data-id=\"499e369\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">What is Drug Repositioning? <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1c24adb elementor-widget elementor-widget-text-editor\" data-id=\"1c24adb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Drug repositioning often refers to taking drugs originally developed for a specific condition but shelved due to safety concerns, regulatory hurdles, or failure to meet clinical trial objectives.<a href=\"https:\/\/www.statnews.com\/2023\/06\/27\/drug-repurposing-repositioning-rare-diseases\/\" target=\"_blank\" rel=\"noopener\">*<\/a> Some drugs may have passed clinical trials and received regulatory approval but are shelved for reasons such as lack of funding, market saturation, intellectual property issues, or changes in business strategy. These drugs can be re-evaluated to determine if they could be useful for treating other diseases.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-99ce096 elementor-widget elementor-widget-text-editor\" data-id=\"99ce096\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The key difference between drug repositioning and drug repurposing is that repositioning involves drugs that were abandoned or shelved, whereas repurposing typically involves drugs that are still in use but being tested for new indications. Repositioning can involve drugs being tested for new uses within the same or even a different therapeutic area. This approach allows researchers to save time by utilising existing clinical data, though overcoming previous safety or efficacy concerns can be a challenge.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c68a996 elementor-widget elementor-widget-spacer\" data-id=\"c68a996\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0c8f190 elementor-widget elementor-widget-menu-anchor\" data-id=\"0c8f190\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"KeyBenefits\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9ba840c elementor-widget elementor-widget-image\" data-id=\"9ba840c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2025\/01\/drug-repurposing.webp\" title=\"drug repurposing\" alt=\"As a healthcare professional, it is important to understand the difference between \u201cdrug repurposing\u201d and \u201cdrug repositioning.\u201d The terms are often used interchangeably but can have different processes and regulatory implications in drug development. Here, you will learn about the differences between the two terms with real-world examples of repurposed drugs and repositioned drugs.\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8f25740 elementor-widget elementor-widget-spacer\" data-id=\"8f25740\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9a60009 elementor-widget elementor-widget-heading\" data-id=\"9a60009\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Key Benefits of Drug Repurposing and Drug Repositioning: <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-38714e8 elementor-widget elementor-widget-text-editor\" data-id=\"38714e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Both drug repurposing and drug repositioning offer significant cost and time efficiencies. Since the drugs are already developed and have undergone safety testing, both processes can shorten the drug development timeline and reduce costs compared to developing a new drug from scratch.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-741fd32 elementor-widget elementor-widget-text-editor\" data-id=\"741fd32\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Both strategies allow for faster access to treatments for diseases with unmet medical needs, especially when urgent therapies are required. By leveraging existing drugs, both approaches have the potential to improve patient outcomes quickly, using therapies that have already demonstrated some level of safety and effectiveness. This strategy was extensively explored and implemented during the COVID-19 pandemic as part of the emergency response.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-887ce46 elementor-widget elementor-widget-text-editor\" data-id=\"887ce46\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Main Differences:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0589351 elementor-widget elementor-widget-text-editor\" data-id=\"0589351\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li>Drug repurposing tends to be faster and more straightforward because the drugs are still actively used in the market and have established safety profiles. This means repurposed drugs can be brought to market more quickly, often benefiting from expedited approval processes for new indications.<\/li><br>\n \t<li>Drug repositioning, on the other hand, may involve shelved drugs that failed in earlier trials or were abandoned for safety or commercial reasons. While drug repositioning can offer new therapeutic benefits, it may be slower and more complex due to the need to address previous safety or efficacy concerns. However, repositioning allows for a more targeted approach, re-evaluating drugs that were once dismissed, potentially providing new treatments for diseases.<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5a8677e elementor-widget elementor-widget-menu-anchor\" data-id=\"5a8677e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"KeyRisks\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4f16f6c elementor-widget elementor-widget-spacer\" data-id=\"4f16f6c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f6b5988 elementor-widget__width-initial elementor-widget elementor-widget-image\" data-id=\"f6b5988\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2025\/01\/drug-repositioning.jpg\" title=\"drug repositioning\" alt=\"drug repositioning\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ec159a1 elementor-widget elementor-widget-spacer\" data-id=\"ec159a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a6974e elementor-widget elementor-widget-heading\" data-id=\"1a6974e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Key risks of Drug Repurposing and Drug Repositioning: <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1ad237c elementor-widget elementor-widget-text-editor\" data-id=\"1ad237c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Both drug repurposing and drug repositioning involve using existing drugs to treat new conditions, but they carry similar risks related to efficacy, safety, and regulatory approval. For both processes, the primary concern is whether the drug will be effective for its new indication and its potential market value.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1634ec6 elementor-widget elementor-widget-text-editor\" data-id=\"1634ec6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Although the drug may have been tested for safety in its original use, unanticipated side effects or drug interactions can arise when used for different diseases. Additionally, both processes face regulatory hurdles, as new trials and data may be needed to gain approval for the new use.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d4d3d49 elementor-widget elementor-widget-text-editor\" data-id=\"d4d3d49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Main Differences:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a6b08f elementor-widget elementor-widget-text-editor\" data-id=\"1a6b08f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li><strong>Repurposed drugs<\/strong> generally have a more established safety profile, which means the risk to patients is somewhat lower compared to repositioned drugs. However, repurposing still carries the risk that the drug may not work for the new condition, have unexpected side effects, or it could face market competition from established treatments.<br><br>Drug repurposing for COVID-19 faced several challenges, leading to risks to patient safety.* Drugs used for malaria and Ebola were proposed based on early-stage studies or theoretical benefits, but larger clinical trials often failed to confirm their effectiveness. Despite insufficient evidence, some medications were promoted as treatments. The lack of solid data, unclear dosing information, drug interactions, hasty regulatory approvals, and public confusion all contributed to adverse outcomes.*<\/li><br>\n \t<li><strong>Repositioned drugs<\/strong> often face higher risks if they were originally shelved due to unresolved safety or efficacy concerns, rather than commercial factors like market saturation. Drugs with a commercial history of failure may struggle to secure funding or regain market confidence. For drugs that failed due to safety or clinical concerns, repositioning may require more extensive regulatory scrutiny compared to already approved drugs being repurposed for new indications.<\/li>\n<\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0a8c956 elementor-widget elementor-widget-text-editor\" data-id=\"0a8c956\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The case of TGN1412 illustrates the risks of drug repositioning.<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC2964774\/\" target=\"_blank\" rel=\"noopener\">*<\/a> Initially developed as an immunotherapy for cancer in the early 2000s, it was shelved after severe adverse effects in early trials. Attempts to reposition it for autoimmune diseases in 2006 failed due to unresolved safety concerns, leading to its discontinuation for all uses. This underscores the risks of using drugs with prior safety issues, as these concerns can prevent success in new indications.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6f82afd elementor-widget elementor-widget-menu-anchor\" data-id=\"6f82afd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"Examplesofdrugrepurposing\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1e446ea elementor-widget elementor-widget-spacer\" data-id=\"1e446ea\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6645a9a elementor-widget elementor-widget-image\" data-id=\"6645a9a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2025\/01\/drug-development-1.jpg\" title=\"drug development\" alt=\"drug development\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-879e1f1 elementor-widget elementor-widget-spacer\" data-id=\"879e1f1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-df0d541 elementor-widget elementor-widget-heading\" data-id=\"df0d541\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Examples of Drug Repurposing and Drug Repositioning <\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9b06745 elementor-widget elementor-widget-heading\" data-id=\"9b06745\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Drug Repurposing Examples: <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-979983d elementor-widget elementor-widget-text-editor\" data-id=\"979983d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li><strong>Ketamine for Depression<a href=\"https:\/\/www.health.harvard.edu\/blog\/ketamine-for-treatment-resistant-depression-when-and-where-is-it-safe-202208092797\" target=\"_blank\" rel=\"noopener\">*<\/a><\/strong><\/li>\n<\/ul>\n<strong>Original Use:<\/strong> Developed in the 1960s as an anaesthetic, ketamine was widely used in medical and surgical settings for pain management and as a general anaesthetic.\n<br><br>\n<strong>Repurposed Use:<\/strong> In 2019, the FDA approved esketamine, a nasal spray formulation of ketamine\u2019s active S-enantiomer, for the treatment of treatment-resistant depression. The treatment offers a faster-acting alternative to traditional antidepressants and is typically used in conjunction with an oral antidepressant for patients who do not respond to other treatments.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-67dc63b elementor-widget elementor-widget-text-editor\" data-id=\"67dc63b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li><strong>CAR-T Cell Therapy for Lupus<a href=\"https:\/\/lupusuk.org.uk\/2024\/11\/08\/car-t-cell-therapy-and-lupus-what-you-need-to-know\/#:~:text=CAR%2DT%20therapy%20and%20lupus,very%20promising%20and%20exciting%20result.\" target=\"_blank\" rel=\"noopener\">*<\/a><\/strong><\/li>\n<\/ul>\n<strong>Original Use:<\/strong> Developed as a cancer treatment in the early 2000s, specifically for blood cancers like leukaemia and lymphoma.\n<br><br>\n<strong>Repurposed Use:<\/strong> A small clinical trial in 2022 showed promising results using CAR-T cell therapy to treat lupus. It is currently being explored as a potential treatment for autoimmune diseases, including lupus, due to its ability to target specific immune cells. However, more research is needed to determine its long-term safety and efficacy for lupus.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3ac9f4e elementor-widget elementor-widget-heading\" data-id=\"3ac9f4e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h4 class=\"elementor-heading-title elementor-size-default\">Drug Repositioning Examples: <\/h4>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9c4af21 elementor-widget elementor-widget-text-editor\" data-id=\"9c4af21\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li><strong>Sildenafil for Pulmonary Hypertension<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33226665\/#:~:text=Sildenafil%2C%20approved%20two%20decades%20ago,pulmonary%20arterial%20hypertension%20(PAH).\" target=\"_blank\" rel=\"noopener\">*<\/a><\/strong><\/li><\/ul><p><strong>Original Use:<\/strong> Sildenafil was developed in the early 1990s as a treatment for angina (chest pain) and was initially tested in clinical trials. However, it was shelved after initial trials showed it did not effectively treat angina.<\/p><p><strong>Repurposed Use:<\/strong> During clinical trials for angina, researchers noticed a side effect: sildenafil caused erections in male participants. This observation led to repositioning the drug for erectile dysfunction, resulting in the approval of Viagra in 1998. Further studies showed sildenafil\u2019s effectiveness for pulmonary hypertension, leading to its approval for this use in 2005. It has since become a widely used treatment, significantly improving patients\u2019 quality of life.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a124bbc elementor-widget elementor-widget-text-editor\" data-id=\"a124bbc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul>\n \t<li><strong>Thalidomide for Multiple Myeloma<a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3573415\/\" target=\"_blank\" rel=\"noopener\">*<\/a><\/strong><\/li>\n<\/ul>\n<strong>Original Use:<\/strong> Thalidomide was originally developed in the 1950s as a sedative and prescribed to pregnant women for morning sickness. However, it was withdrawn from the market after being linked to severe birth defects.\n<br><br>\n<strong>Repurposed Use:<\/strong> In the 1990s, thalidomide was repositioned for the treatment of multiple myeloma, a type of blood cancer, after studies showed it had anti-inflammatory and anti-cancer properties. Thalidomide was approved in 2006 for the treatment of multiple myeloma and other cancers, significantly improving patient outcomes when used in combination with other therapies.\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e5917f0 elementor-widget elementor-widget-text-editor\" data-id=\"e5917f0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0<\/p><p>Were you aware of the differences between drug repurposing and drug repositioning as a doctor? Let us know your thoughts on the topic in the <a href=\"#comments\">comment section below.<\/a><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a0e290 elementor-widget elementor-widget-spacer\" data-id=\"7a0e290\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3138c4c elementor-share-buttons--view-icon elementor-share-buttons--skin-minimal elementor-share-buttons--shape-circle elementor-share-buttons--color-custom elementor-grid-0 elementor-widget elementor-widget-share-buttons\" data-id=\"3138c4c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"share-buttons.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-grid\" role=\"list\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" 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16.3-30.3 1.8-3.7.9-6.9-.5-9.7-1.4-2.8-12.5-30.1-17.1-41.2-4.5-10.8-9.1-9.3-12.5-9.5-3.2-.2-6.9-.2-10.6-.2-3.7 0-9.7 1.4-14.8 6.9-5.1 5.6-19.4 19-19.4 46.3 0 27.3 19.9 53.7 22.6 57.4 2.8 3.7 39.1 59.7 94.8 83.8 35.2 15.2 49 16.5 66.6 13.9 10.7-1.6 32.8-13.4 37.4-26.4 4.6-13 4.6-24.1 3.2-26.4-1.3-2.5-5-3.9-10.5-6.6z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_linkedin\" role=\"button\" tabindex=\"0\" aria-label=\"Share on linkedin\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fab-linkedin\" viewBox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M416 32H31.9C14.3 32 0 46.5 0 64.3v383.4C0 465.5 14.3 480 31.9 480H416c17.6 0 32-14.5 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12.995 1.624 19.818 1.624 9.421 0 18.843-1.3 27.614-3.573-48.081-9.747-84.143-51.98-84.143-102.985v-1.299c13.969 7.797 30.214 12.67 47.431 13.319-28.264-18.843-46.781-51.005-46.781-87.391 0-19.492 5.197-37.36 14.294-52.954 51.655 63.675 129.3 105.258 216.365 109.807-1.624-7.797-2.599-15.918-2.599-24.04 0-57.828 46.782-104.934 104.934-104.934 30.213 0 57.502 12.67 76.67 33.137 23.715-4.548 46.456-13.32 66.599-25.34-7.798 24.366-24.366 44.833-46.132 57.827 21.117-2.273 41.584-8.122 60.426-16.243-14.292 20.791-32.161 39.308-52.628 54.253z\"><\/path><\/svg>\t\t\t\t\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-grid-item\" role=\"listitem\">\n\t\t\t\t\t\t<div class=\"elementor-share-btn elementor-share-btn_pinterest\" role=\"button\" tabindex=\"0\" aria-label=\"Share on pinterest\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"elementor-share-btn__icon\">\n\t\t\t\t\t\t\t\t<svg aria-hidden=\"true\" 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data-id=\"cdfd620\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4584a48 e-flex e-con-boxed e-con e-child\" data-id=\"4584a48\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2c517d4 e-con-full e-flex e-con e-child\" data-id=\"2c517d4\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9cedbde elementor-widget elementor-widget-spacer\" data-id=\"9cedbde\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b734fc0 e-flex e-con-boxed e-con e-child\" data-id=\"b734fc0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7185b6b elementor-widget elementor-widget-heading\" data-id=\"7185b6b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Are You a Healthcare Professional?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9aa126b elementor-widget elementor-widget-text-editor\" data-id=\"9aa126b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Did you enjoy this article? <br \/>Join our community of healthcare professionals to share your opinion<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bf0f82a e-flex e-con-boxed e-con e-child\" data-id=\"bf0f82a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4d20d4d elementor-widget elementor-widget-spacer\" data-id=\"4d20d4d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a4c239d elementor-widget elementor-widget-spacer\" data-id=\"a4c239d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e73bb43 elementor-widget elementor-widget-heading\" data-id=\"e73bb43\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">You Might Be Interested in:<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e6175c elementor-widget elementor-widget-menu-anchor\" data-id=\"9e6175c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"commentdementia\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c01c267 elementor-hidden-desktop elementor-hidden-tablet elementor-hidden-mobile e-flex e-con-boxed e-con e-child\" data-id=\"c01c267\" data-element_type=\"container\" data-e-type=\"container\" data-settings=\"{&quot;background_background&quot;:&quot;gradient&quot;}\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2298818 e-con-full e-flex e-con e-child\" data-id=\"2298818\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b107cca elementor-widget elementor-widget-spacer\" data-id=\"b107cca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1851591 e-flex e-con-boxed e-con e-child\" data-id=\"1851591\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ec706a8 elementor-widget 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What are the regulatory implications in drug development?\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.m3globalresearch.com\/blog\/difference-between-drug-repurposing-drug-repositioning-examples\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The Difference Between Drug Repurposing and Drug Repositioning\" \/>\n<meta property=\"og:description\" content=\"What are the regulatory implications in drug development?\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.m3globalresearch.com\/blog\/difference-between-drug-repurposing-drug-repositioning-examples\/\" \/>\n<meta property=\"og:site_name\" content=\"M3 Global Research\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/en-gb.facebook.com\/M3GlobalResearch\/\" \/>\n<meta property=\"article:published_time\" content=\"2025-01-15T09:09:07+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-05-19T16:34:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2025\/01\/The-Difference-Between-Drug-Repurposing-and-Drug-Repositioning-with-Examples-.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"2309\" \/>\n\t<meta property=\"og:image:height\" content=\"1299\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"m3gr-blog-admin\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:title\" content=\"The Difference Between Drug Repurposing and Drug Repositioning\" \/>\n<meta name=\"twitter:description\" content=\"What are the regulatory implications in drug development?\" \/>\n<meta name=\"twitter:creator\" content=\"@M3GR_Community\" \/>\n<meta name=\"twitter:site\" 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