{"id":140780,"date":"2023-01-25T12:29:02","date_gmt":"2023-01-25T12:29:02","guid":{"rendered":"https:\/\/m3globalresearch.blog\/?p=140780"},"modified":"2023-01-25T12:29:02","modified_gmt":"2023-01-25T12:29:02","slug":"vagus-nerve-stimulation-applications-neurological-disorders","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/vagus-nerve-stimulation-applications-neurological-disorders\/","title":{"rendered":"Vagus Nerve Stimulation and Applications for Neurological Disorders","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"140780\" class=\"elementor elementor-140780\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f21c53a e-flex e-con-boxed e-con e-parent\" data-id=\"f21c53a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-1513451 e-flex e-con-boxed e-con e-child\" data-id=\"1513451\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0a25daf e-flex e-con-boxed e-con e-child\" data-id=\"0a25daf\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-adb5429 elementor-widget elementor-widget-heading\" data-id=\"adb5429\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">*The translation of this article in French and Portuguese has been made through machine translation and has not been edited yet. we apologise for any inaccuracies.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-14fc499 elementor-widget elementor-widget-text-editor\" data-id=\"14fc499\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>As a neurologist, what are your thoughts on vagus nerve stimulation (VNS) therapy? Recent studies have shown that VNS therapy and selective VNS (sVNS) therapy could have significant potential in help treating various neurological disorders including Alzheimer&#8217;s disease, Parkinson&#8217;s disease, and stroke, among others.<\/strong><\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b6bb39 elementor-widget elementor-widget-text-editor\" data-id=\"7b6bb39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Vagus nerve stimulation treatment, also called VNS therapy, is currently used and FDA-approved for epileptic seizures, depression, and pain management<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8888683\/\" target=\"_blank\" rel=\"noopener\">*<\/a>. In recent years VNS therapy has proven to be effective for many other clinical applications. Due to its therapeutic efficacy, there is considerable pressure to optimise the implementation of VNS and it is currently being explored as a potential treatment for neurological disorders including Alzheimer&#8217;s, Parkinson&#8217;s, autistic spectrum disorder, traumatic brain injury, and stroke<a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/33894241\/\" target=\"_blank\" rel=\"noopener\">*<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11fb8e7 elementor-widget elementor-widget-text-editor\" data-id=\"11fb8e7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Vagus nerve stimulation involves implanting a small device in a person\u2019s neck that sends regular, mild pulses of electrical energy to the brainstem through the vagus nerve. After reaching the brainstem, the electrical charge is discharged to different areas of the brain and in doing so changes the way brain cells work. The vagus nerve is one of the most promising targets for neuromodulation, being the longest nerve in the autonomic nervous system.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20caab2 elementor-widget elementor-widget-text-editor\" data-id=\"20caab2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>There is one vagus nerve on each side of the body, connected to several organs, including the heart, lungs, larynx, pharynx, stomach, spleen, pancreas, liver, intestines, and ovaries. The vagus nerve also projects to areas within the brain and central nervous system, including the nucleus tractus solitarius, locus coeruleus, thalamus, hippocampus, amygdala and other regions<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.685872\/full\" target=\"_blank\" rel=\"noopener\">*<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f48c22 elementor-widget elementor-widget-spacer\" data-id=\"9f48c22\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-25f7858 e-flex e-con-boxed e-con e-child\" data-id=\"25f7858\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-efb6fb0 elementor-widget elementor-widget-image\" data-id=\"efb6fb0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2023\/01\/vagus-nerve-stimulation-scaled.jpg\" title=\"vagus nerve stimulation\" alt=\"As a neurologist, what are your thoughts on vagus nerve stimulation (VNS) therapy? Recent studies have shown that VNS therapy and selective VNS (sVNS) therapy could have significant potential in help treating various neurological disorders including Alzheimer&#039;s disease, Parkinson&#039;s disease, and stroke, among others.\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4596bcf elementor-widget elementor-widget-spacer\" data-id=\"4596bcf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8d52b7c elementor-widget elementor-widget-heading\" data-id=\"8d52b7c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">FDA-Approved VNS Treatments<\/h3>\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e85c055 e-flex e-con-boxed e-con e-child\" data-id=\"e85c055\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-799af13 elementor-widget elementor-widget-text-editor\" data-id=\"799af13\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Vagus nerve stimulation with electrical impulses was first FDA-approved in the 1980s to treat drug-resistant epilepsy. Since then the technology, the VNS devices, and surgical procedures have evolved. New research and clinical trials have helped researchers develop new frameworks and methods to better stimulate the vagus nerve in ways that targeting specific fiber types within the nerve to produce specific effects.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29996d5 elementor-widget elementor-widget-text-editor\" data-id=\"29996d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In 2005, VNS therapy was approved by the FDA for treatment-resistant depression such as severe, recurrent unipolar and bipolar depression. The implanted VNS device sends electrical impulses to the left vagus nerve, stimulating the subcortical, and cortical regions of the brain known to be associated with mood regulation<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S0022510X22000302\" target=\"_blank\" rel=\"noopener\">*<\/a>. The neuromodulation shifts the focus from the monoamine synapse to neural circuitry of the brain, which is dysregulated in depression.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-411fae5 elementor-widget elementor-widget-text-editor\" data-id=\"411fae5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Research and clinical trials continue to better understand exactly how VNS changes brain wave patterns that help reduce or eliminate symptoms of depression. Although this type of treatment is not yet fully understood, it has been proven to s improve quality of life in severely depressed patients.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b1aae39 elementor-widget elementor-widget-text-editor\" data-id=\"b1aae39\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>WHO estimates that 5% of adults suffer from depression globally<a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression\" target=\"_blank\" rel=\"noopener\">*<\/a>. Chronic or severe depression affect up to 1.5% of the general population, and many of these patients obtain little relief from pharmaceutical treatment<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5961632\/\" target=\"_blank\" rel=\"noopener\">*<\/a>. The neurological community continues to investigate the psychiatric benefits of VNS to help improve these numbers.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70cb0ff elementor-widget elementor-widget-text-editor\" data-id=\"70cb0ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In recent years, the applications of VNS have also extended to pain management. In 2018, the first non-invasive vagus nerve stimulation (nVNS) device was FDA-approved for migraine and cluster headache. The so called \u201cnon-invasive\u201d method describes VNS treatments that do not require any surgical implantation. Instead, the vagus nerve is stimulated with electrical pulses with the help of a device applied directly to the skin. Patients apply gel to the side of their neck, and then hold the VND device to the same area while it dispenses a mild electrical stimulation through the skin and to the vagus nerve. Studies show that patients experienced a 50% reduction in pain, with nearly 40% being pain-free from migraine attacks and cluster headaches after nVNS treatment<a href=\"https:\/\/utswmed.org\/medblog\/new-migraine-treatments\/\" target=\"_blank\" rel=\"noopener\">*<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d581787 elementor-widget elementor-widget-spacer\" data-id=\"d581787\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93352f7 elementor-widget elementor-widget-menu-anchor\" data-id=\"93352f7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"1\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-42cf640 e-flex e-con-boxed e-con e-child\" data-id=\"42cf640\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-62bab8e elementor-widget elementor-widget-image\" data-id=\"62bab8e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2023\/01\/VNS-therapy.jpg\" title=\"VNS therapy\" alt=\"As a neurologist, what are your thoughts on vagus nerve stimulation (VNS) therapy? Recent studies have shown that VNS therapy and selective VNS (sVNS) therapy could have significant potential in help treating various neurological disorders including Alzheimer&#039;s disease, Parkinson&#039;s disease, and stroke, among others.\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4dc2225 elementor-widget elementor-widget-spacer\" data-id=\"4dc2225\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9608d8f elementor-widget elementor-widget-heading\" data-id=\"9608d8f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Selective VNS (sVNS) Framework and Reduced Side Effects<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bbc75dc elementor-widget elementor-widget-text-editor\" data-id=\"bbc75dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>As research continues, new methods and applications of VNS are still being discovered. Until recently, vagus nerve stimulation had generally been non-selective, resulting in a range of side effects including throat pain, headaches, difficulty swallowing, voice changes, and infections. selective VNS therapy aims to mitigate this by targeting specific fibre types within the nerve, instead of stimulating the whole nerve, to increase efficacy and specificity of the treatment.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c650b8a elementor-widget elementor-widget-text-editor\" data-id=\"c650b8a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The major challenge of VNS development and achieving better selectivity of VNS is a limited knowledge of functional anatomical organisation of the vagus nerve. Despite extensive research over the last century, this remains poorly understood. To avoid off-target effects and improve overall efficacy of VNS, it will be crucial to optimise electrode array geometry and pulse shape, as well as expanding the applications of selective VNS therapy beyond the current focus on certain disease areas<a href=\"https:\/\/www.frontiersin.org\/articles\/10.3389\/fnins.2021.685872\/full\" target=\"_blank\" rel=\"noopener\">*<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e32d523 elementor-widget elementor-widget-text-editor\" data-id=\"e32d523\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Most of the recent research in sVNS has focused on applications for cardiovascular disease. However, with a better understanding of the vagus nerve and its development in surgical procedures, other areas can be explored, including neurological disorders.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7b57912 elementor-widget elementor-widget-spacer\" data-id=\"7b57912\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-20ba592 elementor-widget elementor-widget-menu-anchor\" data-id=\"20ba592\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"menu-anchor.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-menu-anchor\" id=\"2\"><\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-557dc82 elementor-widget elementor-widget-image\" data-id=\"557dc82\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2023\/01\/neurological-disorders-scaled.jpg\" title=\"neurological disorders\" alt=\"As a neurologist, what are your thoughts on vagus nerve stimulation (VNS) therapy? Recent studies have shown that VNS therapy and selective VNS (sVNS) therapy could have significant potential in help treating various neurological disorders including Alzheimer&#039;s disease, Parkinson&#039;s disease, and stroke, among others.\" loading=\"lazy\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c71dd48 elementor-widget elementor-widget-spacer\" data-id=\"c71dd48\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e74efbe elementor-widget elementor-widget-heading\" data-id=\"e74efbe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">New Applications for VNS Therapy, and Market Outlook<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0800269 elementor-widget elementor-widget-text-editor\" data-id=\"0800269\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The demand for VNS therapy is steadily increasing. Interest in new VNS treatments, from both the medical community as well the general public has grown immensely in recent years, and is anticipated to continue doing so.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-492ca53 elementor-widget elementor-widget-text-editor\" data-id=\"492ca53\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The global vagus nerve stimulation market is expected to grow with a 15% compound annual growth rate (CAGR) between 2022 and 2029, reaching $2,424.01 million USD by 2029*. Some recent areas of focus for new VNS applications include anti-inflammatory treatments. Leading companies of the VNS industry are engaging in various developmental activities and extensive market research will be needed to re-launch updated products in the market. In line with this trend, neurologists will be in high demand to share their expert opinions and help manufacturers gain insight into how to further develop VNS products to improve patient outcomes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-00a8af6 elementor-widget elementor-widget-text-editor\" data-id=\"00a8af6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Recent studies of VNS have shown that it has anti-inflammatory properties which has driven more preclinical research aimed at expanding VNS treatment across a wider range of inflammatory disorders such as Crohn\u2019s disease, irritable bowel syndrome, sepsis, lung injury, rheumatoid arthritis, diabetes, and fibromyalgia<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5961632\/\" target=\"_blank\" rel=\"noopener\">*<\/a>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d9f06d elementor-widget elementor-widget-text-editor\" data-id=\"3d9f06d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Because research hasn\u2019t been published yet, the efficacy of VNS treatment for these disorders is currently unknown. However, new preclinical research shows that VNS has significant potential for being applied to a wider range of therapeutic applications, including neurological disorders.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8d4aa9f elementor-widget elementor-widget-text-editor\" data-id=\"8d4aa9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The links below provide further reading on some of the new applications of VNS applications that are currently being explored for neurological disease areas. If you work as a neurologist and are interested in sharing your opinions about treatments and products for neurological disorders, you can sign up below to participate in paid market research studies within neurology.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-50c11d8 e-flex e-con-boxed e-con e-child\" data-id=\"50c11d8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-712c4af elementor-widget elementor-widget-text-editor\" data-id=\"712c4af\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<ul><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC9098960\/\" target=\"_blank\" rel=\"noopener\">Vagus Nerve Stimulation as a Potential Therapy in Early Alzheimer\u2019s Disease<\/a> (PubMed, 2022)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34461787\/\" target=\"_blank\" rel=\"noopener\">Noninvasive vagus nerve stimulation in Parkinson&#8217;s Disease<\/a> (PubMed, 2021)<\/li><li><a href=\"https:\/\/www.mdpi.com\/2673-4087\/2\/3\/18\" target=\"_blank\" rel=\"noopener\">Treating Traumatic Brain Injuries with Electroceuticals<\/a> (MDPI, 2021)<\/li><li><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/30732986\/\" target=\"_blank\" rel=\"noopener\">Neuromodulation of autism spectrum disorders using vagal nerve stimulation<\/a> (PubMed, 2019)<\/li><li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC8888683\/\" target=\"_blank\" rel=\"noopener\">Non-invasive Vagus Nerve Stimulation in Cerebral Stroke<\/a> (PubMed, 2022) <\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-61855fc e-flex e-con-boxed e-con e-child\" data-id=\"61855fc\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f109ad7 elementor-widget elementor-widget-text-editor\" data-id=\"f109ad7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>If you have come across any other interesting applications of VNS therapy, please let us know by sharing your thoughts in the comment section below or <a href=\"https:\/\/www.linkedin.com\/company\/10557915\" target=\"_blank\" rel=\"noopener\">follow us on LinkedIn<\/a> for the latest updates.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-0db5bb7 elementor-widget elementor-widget-text-editor\" data-id=\"0db5bb7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>You may also be interested in continuing reading about how to earn extra income with <a href=\"https:\/\/m3globalresearch.blog\/2022\/12\/14\/paid-medical-surveys-for-physicians\/\">paid medical surveys for physicians<\/a>, or check out &#8220;<a href=\"https:\/\/m3globalresearch.blog\/available-medical-studies\/\">Available Medical Studies<\/a>&#8221; for neurologists.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-01a52de elementor-widget elementor-widget-spacer\" data-id=\"01a52de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cbc5f01 elementor-hidden-mobile elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cbc5f01\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ec2cc59\" data-id=\"ec2cc59\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b11b91b elementor-cta--layout-image-left elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"b11b91b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-cta\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2022\/12\/market-research-in-healthcare-1024x683.jpg);\" role=\"img\" aria-label=\"market research in healthcare\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tDid you find this article about vagus nerve stimulation, VNS therapy and selective VNS therapy interesting? We would like to invite you to participate in surveys to improve the treatment of neurological disorders. Join today to take part in market research in healthcare.\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item \">\n\t\t\t\t\t<a class=\"elementor-cta__button elementor-button elementor-size-\" href=\"https:\/\/www.m3globalresearch.com\/research\/?hh_id=49572&#038;utm_source=Blog%2FTop6driven&#038;utm_medium=VNS-o-Pic&#038;utm_campaign=49572%09Blog+Vagus+Nerve+Stimulation&#038;utm_id=49572&#038;utm_content=Signup\">\n\t\t\t\t\t\tSign up\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-99883b9 elementor-hidden-tablet elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"99883b9\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-ca80a28\" data-id=\"ca80a28\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-fd99175 elementor-cta--layout-image-above elementor-hidden-desktop elementor-hidden-tablet elementor-cta--skin-classic elementor-animated-content elementor-bg-transform elementor-bg-transform-zoom-in elementor-widget elementor-widget-call-to-action\" data-id=\"fd99175\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"call-to-action.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-cta\">\n\t\t\t\t\t<div class=\"elementor-cta__bg-wrapper\">\n\t\t\t\t<div class=\"elementor-cta__bg elementor-bg\" style=\"background-image: url(https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2022\/12\/market-research-in-healthcare-1024x683.jpg);\" role=\"img\" aria-label=\"market research in healthcare\"><\/div>\n\t\t\t\t<div class=\"elementor-cta__bg-overlay\"><\/div>\n\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"elementor-cta__content\">\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__description elementor-cta__content-item elementor-content-item\">\n\t\t\t\t\t\tDid you find this article about vagus nerve stimulation, selective VNS therapy and selective VNS therapy interesting? We would like to invite you to participate in surveys to improve the treatment of neurological disorders. Join today to take part in market research in healthcare.\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-cta__button-wrapper elementor-cta__content-item elementor-content-item \">\n\t\t\t\t\t<a class=\"elementor-cta__button elementor-button elementor-size-\" href=\"https:\/\/www.m3globalresearch.com\/research\/?hh_id=49572&#038;utm_source=Blog%2FTop6driven&#038;utm_medium=VNS-o-Pic&#038;utm_campaign=49572%09Blog+Vagus+Nerve+Stimulation&#038;utm_id=49572&#038;utm_content=Signup\">\n\t\t\t\t\t\tSign up\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t<div class=\"elementor-element elementor-element-c8132d6 e-flex e-con-boxed e-con e-parent\" data-id=\"c8132d6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c418a9d elementor-widget elementor-widget-spacer\" data-id=\"c418a9d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-11fc4a4 elementor-widget elementor-widget-heading\" data-id=\"11fc4a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\">Learn More About Market Research in Healthcare<\/h3>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f06113b e-flex e-con-boxed e-con e-parent\" data-id=\"f06113b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9099cbb elementor-grid-1 elementor-grid-tablet-1 elementor-posts--thumbnail-left elementor-grid-mobile-1 elementor-widget elementor-widget-posts\" data-id=\"9099cbb\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;classic_columns&quot;:&quot;1&quot;,&quot;classic_columns_tablet&quot;:&quot;1&quot;,&quot;classic_row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:50,&quot;sizes&quot;:[]},&quot;classic_columns_mobile&quot;:&quot;1&quot;,&quot;classic_row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;classic_row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"posts.classic\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-posts-container elementor-posts elementor-posts--skin-classic elementor-grid\" role=\"list\">\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-170012 post type-post status-publish format-standard has-post-thumbnail hentry category-mental-health-and-well-being category-sustainable-practice\" role=\"listitem\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"https:\/\/www.m3globalresearch.com\/blog\/7-ways-say-no-extra-work-staying-collaborative\/\" tabindex=\"-1\" >\n\t\t\t<div class=\"elementor-post__thumbnail\"><img fetchpriority=\"high\" decoding=\"async\" width=\"7936\" height=\"5291\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/05\/saying-no-at-work-scaled.jpeg\" class=\"attachment-full size-full wp-image-170060\" alt=\"Improve managing workload by setting boundaries in healthcare and mastering saying no at work with clear clinical workload boundaries.\" \/><\/div>\n\t\t<\/a>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/www.m3globalresearch.com\/blog\/7-ways-say-no-extra-work-staying-collaborative\/\" >\n\t\t\t\t7 Ways to Say &#8216;No&#8217; to Extra Work While Staying Collaborative\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tMay 13, 2026\t\t<\/span>\n\t\t\t\t<span class=\"elementor-post-avatar\">\n\t\t\tNo Comments\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>Improve managing workload by setting boundaries in healthcare and mastering saying no at work with clear clinical workload boundaries.<\/p>\n\t\t<\/div>\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/www.m3globalresearch.com\/blog\/7-ways-say-no-extra-work-staying-collaborative\/\" aria-label=\"Read more about 7 Ways to Say &#8216;No&#8217; to Extra Work While Staying Collaborative\" tabindex=\"-1\" >\n\t\t\tRead More\t\t<\/a>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article class=\"elementor-post elementor-grid-item post-169828 post type-post status-publish format-standard has-post-thumbnail hentry category-latest-medical-news tag-oncology\" role=\"listitem\">\n\t\t\t\t<a class=\"elementor-post__thumbnail__link\" href=\"https:\/\/www.m3globalresearch.com\/blog\/blood-test-identifies-nine-tumour-cell-neighbourhoods-linked-immunotherapy-response\/\" tabindex=\"-1\" >\n\t\t\t<div class=\"elementor-post__thumbnail\"><img decoding=\"async\" width=\"5632\" height=\"3072\" src=\"https:\/\/www.m3globalresearch.com\/blog\/wp-content\/uploads\/2026\/05\/Blood-Test-Identifies-Nine-Tumour-Cell-Neighbourhoods-Linked-to-Immunotherapy-Response-scaled.jpeg\" class=\"attachment-full size-full wp-image-169998\" alt=\"Blood test identifies nine tumour cell neighbourhoods linked to immunotherapy response and tumour mapping without tissue biopsy.\" \/><\/div>\n\t\t<\/a>\n\t\t\t\t<div class=\"elementor-post__text\">\n\t\t\t\t<h3 class=\"elementor-post__title\">\n\t\t\t<a href=\"https:\/\/www.m3globalresearch.com\/blog\/blood-test-identifies-nine-tumour-cell-neighbourhoods-linked-immunotherapy-response\/\" >\n\t\t\t\tBlood Test Identifies Nine Tumour Cell Neighbourhoods Linked to Immunotherapy Response\t\t\t<\/a>\n\t\t<\/h3>\n\t\t\t\t<div class=\"elementor-post__meta-data\">\n\t\t\t\t\t<span class=\"elementor-post-date\">\n\t\t\tMay 12, 2026\t\t<\/span>\n\t\t\t\t<span class=\"elementor-post-avatar\">\n\t\t\tNo Comments\t\t<\/span>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-post__excerpt\">\n\t\t\t<p>Blood test identifies nine tumour cell neighbourhoods linked to immunotherapy response and tumour mapping without tissue biopsy.<\/p>\n\t\t<\/div>\n\t\t\n\t\t<a class=\"elementor-post__read-more\" href=\"https:\/\/www.m3globalresearch.com\/blog\/blood-test-identifies-nine-tumour-cell-neighbourhoods-linked-immunotherapy-response\/\" aria-label=\"Read more about Blood Test Identifies Nine Tumour Cell Neighbourhoods Linked to Immunotherapy Response\" tabindex=\"-1\" >\n\t\t\tRead More\t\t<\/a>\n\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ff640e6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ff640e6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-33 elementor-top-column elementor-element elementor-element-c3d1062\" data-id=\"c3d1062\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-3ef88f8 elementor-widget elementor-widget-spacer\" data-id=\"3ef88f8\" data-element_type=\"widget\" data-e-type=\"widget\" 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data-widget_type=\"spacer.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"excerpt":{"rendered":"<p>Recent studies have shown that VNS therapy and selective VNS (sVNS) therapy could have significant potential in help treating various neurological disorders including Alzheimer\u2019s disease, Parkinson\u2019s disease, and stroke, among others.<\/p>\n","protected":false,"gt_translate_keys":[{"key":"rendered","format":"html"}]},"author":1,"featured_media":140805,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_jetpack_memberships_contains_paid_content":false,"footnotes":""},"categories":[8200,8201],"tags":[354,3623,7773,1872,8202],"class_list":["post-140780","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-healthcare","category-physician-hub","tag-healthcare-market-research","tag-neurology","tag-ph","tag-physician-opinion","tag-vagus-nerve-stimulation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v27.6 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Vagus Nerve Stimulation and Applications for Neurological Disorders<\/title>\n<meta name=\"description\" content=\"Vagus nerve stimulation (VNS). 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