{"id":136299,"date":"2022-10-19T12:03:48","date_gmt":"2022-10-19T11:03:48","guid":{"rendered":"https:\/\/m3globalresearch.blog\/?p=136299"},"modified":"2022-10-19T12:03:48","modified_gmt":"2022-10-19T11:03:48","slug":"polygenic-risk-scores-genetic-risk-assessment","status":"publish","type":"post","link":"https:\/\/www.m3globalresearch.com\/blog\/polygenic-risk-scores-genetic-risk-assessment\/","title":{"rendered":"Polygenic Risk Scores and the Future of Genetic Risk Assessment","gt_translate_keys":[{"key":"rendered","format":"text"}]},"content":{"rendered":"\t\t
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*The translation of this article in French and Portuguese has been made through machine translation and has not been edited yet. we apologise for any inaccuracies.<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Could Polygenetic Risk Scores Be the Future of Risk Assessment and Disease Prevention?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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In a recent study published in Nature Medicine<\/a>, researchers developed and validated polygenic risk scores for six common diseases, which could assist physicians and patients when making medical decisions, risk assessment and disease prevention.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Advancements in medical technology and increasing amounts of genetic data have led to the development of polygenic risk scores (PRS) which can be used to estimate an individual\u2019s genetic risk of developing various common diseases. Implementation of PRS in healthcare systems may improve disease prevention and could potentially be used to optimise the use of screening and preventative treatments and improve personalised care for patients. However, there are still many challenges to overcome before PRS can be clinically utilised for practical disease prevention. Below you will find the results from our monthly M3 Pulse survey, where we asked over 3,000 healthcare professionals globally for their opinions on genetic mapping and the use of polygenic risk scores.<\/p>

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Researchers from Brigham and Women\u2019s Hospital, Veterans Affairs Boston Healthcare System, and Harvard Medical School developed and validated polygenic risk scores for the six common diseases listed below by using data from 36,423 Mass General Brigham Biobank participants. In addition, they developed a physician and patient information guide to support decision-making based on PRS results. The main challenges of implementing PRS have been how to practically incorporate PRS into the medical workflow and help physicians and patients understand and utilise the PRS results to best support the decision-making in their healthcare.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t

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